Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144265655> ?p ?o ?g. }
- W2144265655 endingPage "209" @default.
- W2144265655 startingPage "201" @default.
- W2144265655 abstract "Psoriasis is a common, immunologically mediated, inflammatory and hyperproliferative disease of the skin and joints, with a multifactorial genetic basis. We earlier mapped PSORS1, the major psoriasis susceptibility gene in the major histocompatibility complex (MHC), to within or very near HLA-Cw6. In an effort to identify non-MHC psoriasis genes, we carried out a collaborative genome-wide association study. After the initial follow-up genotyping of 21 single nucleotide polymorphisms from 18 loci, showing strong evidence of association in the initial scan, we confirmed evidence of association at seven loci. Three of these loci confirm earlier reports of association (HLA-C, IL12B, IL23R) and four identify novel signals located near plausible candidate genes (IL23A, IL4/IL13, TNFAIP3 and TNIP1). In other work, we have also shown that interferon-γ (IFN-γ) treatment induces interleukin (IL)-23 mRNA and protein in antigen-presenting cells (APC), leading to the proliferation of CD4+ and CD8+ memory T cells expressing IL-17. Although functional variants remain to be identified, we speculate that genetic variants at the IL4/IL13 locus contribute to the Th1 bias that is characteristic of psoriasis, that Th1-derived IFN-γ supports expansion of IL-17+ T cells through APC-derived IL-23 and that negative regulation of inflammatory signaling through the NF-κB axis is impaired because of genetic variants of TNFAIP3 and TNIP1." @default.
- W2144265655 created "2016-06-24" @default.
- W2144265655 creator A5015004042 @default.
- W2144265655 date "2009-03-05" @default.
- W2144265655 modified "2023-09-27" @default.
- W2144265655 title "Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis" @default.
- W2144265655 cites W1497536259 @default.
- W2144265655 cites W1532206496 @default.
- W2144265655 cites W1916477545 @default.
- W2144265655 cites W1929927945 @default.
- W2144265655 cites W1963819091 @default.
- W2144265655 cites W1964995490 @default.
- W2144265655 cites W1965753425 @default.
- W2144265655 cites W1966731757 @default.
- W2144265655 cites W1970176951 @default.
- W2144265655 cites W1970373563 @default.
- W2144265655 cites W1976833736 @default.
- W2144265655 cites W1978171344 @default.
- W2144265655 cites W1979349547 @default.
- W2144265655 cites W1980569692 @default.
- W2144265655 cites W1981714996 @default.
- W2144265655 cites W1981924240 @default.
- W2144265655 cites W1982380837 @default.
- W2144265655 cites W1982538658 @default.
- W2144265655 cites W1985268664 @default.
- W2144265655 cites W1986170455 @default.
- W2144265655 cites W1988021062 @default.
- W2144265655 cites W1991030828 @default.
- W2144265655 cites W1993273784 @default.
- W2144265655 cites W1994030355 @default.
- W2144265655 cites W1994893503 @default.
- W2144265655 cites W1998000193 @default.
- W2144265655 cites W1998894507 @default.
- W2144265655 cites W1998957301 @default.
- W2144265655 cites W2001787430 @default.
- W2144265655 cites W2002124107 @default.
- W2144265655 cites W2004372679 @default.
- W2144265655 cites W2005359518 @default.
- W2144265655 cites W2005576094 @default.
- W2144265655 cites W2008419958 @default.
- W2144265655 cites W2012077729 @default.
- W2144265655 cites W2013304729 @default.
- W2144265655 cites W2017531605 @default.
- W2144265655 cites W2022665587 @default.
- W2144265655 cites W2023073368 @default.
- W2144265655 cites W2023358234 @default.
- W2144265655 cites W2029101308 @default.
- W2144265655 cites W2030348118 @default.
- W2144265655 cites W2034666462 @default.
- W2144265655 cites W2035093405 @default.
- W2144265655 cites W2035546749 @default.
- W2144265655 cites W2038226782 @default.
- W2144265655 cites W2040111062 @default.
- W2144265655 cites W2040516688 @default.
- W2144265655 cites W2043004968 @default.
- W2144265655 cites W2045113343 @default.
- W2144265655 cites W2048755332 @default.
- W2144265655 cites W2051174436 @default.
- W2144265655 cites W2055514573 @default.
- W2144265655 cites W2056349938 @default.
- W2144265655 cites W2059276529 @default.
- W2144265655 cites W2067041353 @default.
- W2144265655 cites W2069650929 @default.
- W2144265655 cites W2070461385 @default.
- W2144265655 cites W2071343804 @default.
- W2144265655 cites W2073167340 @default.
- W2144265655 cites W2073453659 @default.
- W2144265655 cites W2079267030 @default.
- W2144265655 cites W2086368962 @default.
- W2144265655 cites W2092916655 @default.
- W2144265655 cites W2103533676 @default.
- W2144265655 cites W2106471879 @default.
- W2144265655 cites W2110888991 @default.
- W2144265655 cites W2121126920 @default.
- W2144265655 cites W2124896761 @default.
- W2144265655 cites W2126162679 @default.
- W2144265655 cites W2128218039 @default.
- W2144265655 cites W2133657961 @default.
- W2144265655 cites W2136157736 @default.
- W2144265655 cites W2140079333 @default.
- W2144265655 cites W2141016525 @default.
- W2144265655 cites W2142769596 @default.
- W2144265655 cites W2142875711 @default.
- W2144265655 cites W2143076511 @default.
- W2144265655 cites W2143429821 @default.
- W2144265655 cites W2144974645 @default.
- W2144265655 cites W2145958269 @default.
- W2144265655 cites W2149335113 @default.
- W2144265655 cites W2151013280 @default.
- W2144265655 cites W2151566115 @default.
- W2144265655 cites W2165872127 @default.
- W2144265655 cites W2169758620 @default.
- W2144265655 cites W2170138746 @default.
- W2144265655 cites W2217809488 @default.
- W2144265655 cites W4205200442 @default.
- W2144265655 cites W4240857676 @default.
- W2144265655 cites W4251839213 @default.
- W2144265655 cites W4319308347 @default.