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• W2144309492 abstract "Various types of collagen are known as modulators of mesangial cell proliferation. Here the function of the collagen-binding tyrosine kinase receptor discoidin domain receptor 1 (DDR1) in mesangial cells is investigated. The expression of DDR1 in the mouse kidney is confirmed by Northern analysis. In primary mesangial cells isolated from wild-type and DDR1-null mice, tyrosine phosphorylation in response to collagen-stimulation, adhesion to collagen, and cellular proliferation were measured. DDR1 phosphorylation was induced after overnight incubation of cells with type I collagen. Compared with wild-type cells, the adhesion of DDR1-null cells was drastically reduced. In contrast, DDR1-knockout cells showed significantly enhanced proliferation compared with wild-type cells. Both effects were largely independent of the collagen-binding alpha1/beta1 integrin function. This study found that the increased proliferation rate of DDR1-null cells is caused by a constitutive upregulation of p42/p44 and p38 mitogen-activated protein kinases (MAPK) activity. This is the first evidence indicating that DDR1 could be involved in the proliferative stage of renal disorders." @default.
• W2144309492 created "2016-06-24" @default.
• W2144309492 creator A5010661799 @default.
• W2144309492 creator A5058587113 @default.
• W2144309492 date "2002-11-01" @default.
• W2144309492 modified "2023-10-14" @default.
• W2144309492 title "Discoidin Domain Receptor 1 Controls Growth and Adhesion of Mesangial Cells" @default.
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• W2144309492 doi "https://doi.org/10.1097/01.asn.0000032419.13208.0c" @default.
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