Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144313502> ?p ?o ?g. }
- W2144313502 endingPage "1047" @default.
- W2144313502 startingPage "1037" @default.
- W2144313502 abstract "Introduction: Alport syndrome is a genetic disorder of basement membranes caused by mutations in the type IV collagen genes COL4A3, COL4A4 and COL4A5. The Alport phenotype includes progressive hematuric nephropathy often leading to end-stage renal disease (ESRD), sensorineural deafness and ocular lesions. Results of laboratory and clinical research studies form the basis for current treatment recommendations aimed at delaying ESRD and indicate novel therapeutic approaches that may prevent ESRD altogether in many affected individuals. Areas covered: This review of Alport syndrome therapeutics begins with a summary of current understanding of pathogenetic mechanisms, followed by discussion of intervention targeting tubular injury and interstitial fibrosis, cell-based therapies, modulation of glomerular signaling and gene delivery and manipulation. A PubMed search using the term ‘Alport syndrome’ was used to gather literature for this monograph. Expert opinion: Experimental and clinical data support the early initiation of ACE inhibition to delay the onset of ESRD. Novel therapies targeting disease pathways activated by type IV collagen deficiency in basement membranes have the potential to further improve outcomes, especially in patients with genotypes associated with relatively rapid loss of renal function." @default.
- W2144313502 created "2016-06-24" @default.
- W2144313502 creator A5020901847 @default.
- W2144313502 date "2014-08-06" @default.
- W2144313502 modified "2023-09-23" @default.
- W2144313502 title "Genetics and biological therapies for Alport syndrome" @default.
- W2144313502 cites W1550732922 @default.
- W2144313502 cites W1967934644 @default.
- W2144313502 cites W1968732270 @default.
- W2144313502 cites W1973471682 @default.
- W2144313502 cites W1975379618 @default.
- W2144313502 cites W1985770728 @default.
- W2144313502 cites W1989038991 @default.
- W2144313502 cites W1991407130 @default.
- W2144313502 cites W1991538418 @default.
- W2144313502 cites W2000300682 @default.
- W2144313502 cites W2000915212 @default.
- W2144313502 cites W2001627823 @default.
- W2144313502 cites W2002778380 @default.
- W2144313502 cites W2006505323 @default.
- W2144313502 cites W2017201836 @default.
- W2144313502 cites W2018237806 @default.
- W2144313502 cites W2018793121 @default.
- W2144313502 cites W2025683762 @default.
- W2144313502 cites W2029863361 @default.
- W2144313502 cites W2030339637 @default.
- W2144313502 cites W2030527067 @default.
- W2144313502 cites W2033104468 @default.
- W2144313502 cites W2033233404 @default.
- W2144313502 cites W2033572428 @default.
- W2144313502 cites W2034698282 @default.
- W2144313502 cites W2035041709 @default.
- W2144313502 cites W2040671717 @default.
- W2144313502 cites W2043336522 @default.
- W2144313502 cites W2048156183 @default.
- W2144313502 cites W2049030581 @default.
- W2144313502 cites W2049440576 @default.
- W2144313502 cites W2050489783 @default.
- W2144313502 cites W2056578856 @default.
- W2144313502 cites W2057600239 @default.
- W2144313502 cites W2058691614 @default.
- W2144313502 cites W2060213971 @default.
- W2144313502 cites W2062927700 @default.
- W2144313502 cites W2065717492 @default.
- W2144313502 cites W2066454223 @default.
- W2144313502 cites W2073640525 @default.
- W2144313502 cites W2074207450 @default.
- W2144313502 cites W2074744775 @default.
- W2144313502 cites W2078899838 @default.
- W2144313502 cites W2079186563 @default.
- W2144313502 cites W2083714449 @default.
- W2144313502 cites W2083837591 @default.
- W2144313502 cites W2085887596 @default.
- W2144313502 cites W2092633851 @default.
- W2144313502 cites W2094608156 @default.
- W2144313502 cites W2099530258 @default.
- W2144313502 cites W2101496480 @default.
- W2144313502 cites W2101960634 @default.
- W2144313502 cites W2102396428 @default.
- W2144313502 cites W2103188558 @default.
- W2144313502 cites W2106709135 @default.
- W2144313502 cites W2109297796 @default.
- W2144313502 cites W2114397993 @default.
- W2144313502 cites W2115073390 @default.
- W2144313502 cites W2119619243 @default.
- W2144313502 cites W2124602789 @default.
- W2144313502 cites W2124964208 @default.
- W2144313502 cites W2125903388 @default.
- W2144313502 cites W2130905710 @default.
- W2144313502 cites W2131781415 @default.
- W2144313502 cites W2134382817 @default.
- W2144313502 cites W2135329373 @default.
- W2144313502 cites W2137814381 @default.
- W2144313502 cites W2140255437 @default.
- W2144313502 cites W2142946696 @default.
- W2144313502 cites W2150582334 @default.
- W2144313502 cites W2151383898 @default.
- W2144313502 cites W2153102493 @default.
- W2144313502 cites W2159783577 @default.
- W2144313502 cites W2159864284 @default.
- W2144313502 cites W2164779907 @default.
- W2144313502 doi "https://doi.org/10.1517/21678707.2014.946903" @default.
- W2144313502 hasPublicationYear "2014" @default.
- W2144313502 type Work @default.
- W2144313502 sameAs 2144313502 @default.
- W2144313502 citedByCount "1" @default.
- W2144313502 countsByYear W21443135022017 @default.
- W2144313502 crossrefType "journal-article" @default.
- W2144313502 hasAuthorship W2144313502A5020901847 @default.
- W2144313502 hasConcept C126322002 @default.
- W2144313502 hasConcept C134018914 @default.
- W2144313502 hasConcept C142724271 @default.
- W2144313502 hasConcept C2776115139 @default.
- W2144313502 hasConcept C2776908417 @default.
- W2144313502 hasConcept C2779134260 @default.
- W2144313502 hasConcept C2780091579 @default.
- W2144313502 hasConcept C2780368995 @default.
- W2144313502 hasConcept C2781184683 @default.