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- W2144352257 abstract "Many variables of the QT interval have been used for risk stratification of various cardiovascular diseases. The QT interval represents the repolarization phase of the ventricles, and this phase is important for the process of excitation-contraction (EC) coupling of the myocardium. Changes in electrophysiologic balance in the repolarization phase have the potential for both antiarrhythmic and proarrhythmic effects. Initially, QT interval abnormality (that is, QT prolongation) was recognized in children with sudden death. Almost 60 years passed after the recognition of the first long QT syndrome cases, and the QT interval still is the most important clinical characteristic and predictor of prognosis in patients with long QT syndrome. 1 Morita H. Wu J. Zipes D.P. The QT syndromes: long and short. Lancet. 2008; 372: 750-763 Abstract Full Text Full Text PDF PubMed Scopus (258) Google Scholar QT prolongation has also been applied for prediction of various cardiovascular diseases, and prolonged QT interval has been linked to an increased risk of cardiovascular death. 2 Schwartz P.J. Wolf S. QT interval prolongation as predictor of sudden death in patients with myocardial infarction. Circulation. 1978; 57: 1074-1077 Crossref PubMed Scopus (641) Google Scholar QT variability index on 24-hour Holter independently predicts mortality in patients with heart failure: analysis of Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca (GISSI-HF) trialHeart RhythmVol. 8Issue 8PreviewIncreased temporal variability of repolarization, as reflected by QT interval variability measured over 10–15 minutes, predicted spontaneous ventricular arrhythmias and death in implantable cardioverter-defibrillator patients in mild to moderate heart failure (HF). Full-Text PDF" @default.
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- W2144352257 date "2011-08-01" @default.
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- W2144352257 title "How can we stabilize QT variability?" @default.
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- W2144352257 doi "https://doi.org/10.1016/j.hrthm.2011.04.018" @default.
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