FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144397114> ?p ?o ?g. }

• W2144397114 endingPage "11" @default.
• W2144397114 startingPage "1" @default.
• W2144397114 abstract "Transforming growth factor- β (TGF- β ) has been shown to be involved in diabetic nephropathy (DN). The SnoN protein can regulate TGF- β signaling through interaction with Smad proteins. Recent studies have shown that SnoN is mainly degraded by the ubiquitin-proteasome pathway. However, the role of SnoN in the regulation of TGF- β /Smad signaling in DN is still unclear. In this study, diabetic rats were randomly divided into a diabetic control group (DC group) and a proteasome inhibitor (MG132) diabetes therapy group (DT group). Kidney damage parameters and the expression of SnoN, Smurf2, and TGF- β were observed. Simultaneously, we cultured rat glomerular mesangial cells (GMCs) stimulated with high glucose, and SnoN and Arkadia expression were measured. Results demonstrated that 24-hour urine protein, ACR, BUN, and the expression of Smurf2 and TGF- β were significantly increased (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>), whereas SnoN was significantly decreased in the DC group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>). However, these changes diminished after treatment with MG132. SnoN expression in GMCs decreased significantly (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>), but Arkadia expression gradually increased due to high glucose stimulation (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>), which could be almost completely reversed by MG132 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>). The present results support the hypothesis that MG132 may alleviate kidney damage by inhibiting SnoN degradation and TGF- β activation, suggesting that the ubiquitin-proteasome pathway may become a new therapeutic target for DN." @default.
• W2144397114 created "2016-06-24" @default.
• W2144397114 creator A5008791054 @default.
• W2144397114 creator A5021067194 @default.
• W2144397114 creator A5022166327 @default.
• W2144397114 creator A5024673892 @default.
• W2144397114 creator A5031953660 @default.
• W2144397114 creator A5035235955 @default.
• W2144397114 creator A5042744407 @default.
• W2144397114 creator A5052597944 @default.
• W2144397114 creator A5056694857 @default.
• W2144397114 creator A5063900505 @default.
• W2144397114 creator A5069353507 @default.
• W2144397114 date "2014-01-01" @default.
• W2144397114 modified "2023-10-14" @default.
• W2144397114 title "The Proteasome Inhibitor, MG132, Attenuates Diabetic Nephropathy by Inhibiting SnoN Degradation<i>In Vivo</i>and<i>In Vitro</i>" @default.
• W2144397114 cites W148446906 @default.
• W2144397114 cites W1807203395 @default.
• W2144397114 cites W1969168791 @default.
• W2144397114 cites W1971093570 @default.
• W2144397114 cites W1977390302 @default.
• W2144397114 cites W1979069114 @default.
• W2144397114 cites W1984374042 @default.
• W2144397114 cites W1986446612 @default.
• W2144397114 cites W1997431505 @default.
• W2144397114 cites W2010627219 @default.
• W2144397114 cites W2016789558 @default.
• W2144397114 cites W2040649891 @default.
• W2144397114 cites W2053577841 @default.
• W2144397114 cites W2056571350 @default.
• W2144397114 cites W2074191313 @default.
• W2144397114 cites W2074580711 @default.
• W2144397114 cites W2082199390 @default.
• W2144397114 cites W2084861320 @default.
• W2144397114 cites W2094062881 @default.
• W2144397114 cites W2105509545 @default.
• W2144397114 cites W2124350477 @default.
• W2144397114 cites W2125326130 @default.
• W2144397114 cites W2159744672 @default.
• W2144397114 cites W2170665235 @default.
• W2144397114 cites W2172261623 @default.
• W2144397114 cites W2418348334 @default.
• W2144397114 cites W4231142430 @default.
• W2144397114 doi "https://doi.org/10.1155/2014/684765" @default.
• W2144397114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4070544" @default.
• W2144397114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25003128" @default.
• W2144397114 hasPublicationYear "2014" @default.
• W2144397114 type Work @default.
• W2144397114 sameAs 2144397114 @default.
• W2144397114 citedByCount "21" @default.
• W2144397114 countsByYear W21443971142015 @default.
• W2144397114 countsByYear W21443971142016 @default.
• W2144397114 countsByYear W21443971142017 @default.
• W2144397114 countsByYear W21443971142018 @default.
• W2144397114 countsByYear W21443971142019 @default.
• W2144397114 countsByYear W21443971142020 @default.
• W2144397114 countsByYear W21443971142021 @default.
• W2144397114 countsByYear W21443971142022 @default.
• W2144397114 countsByYear W21443971142023 @default.
• W2144397114 crossrefType "journal-article" @default.
• W2144397114 hasAuthorship W2144397114A5008791054 @default.
• W2144397114 hasAuthorship W2144397114A5021067194 @default.
• W2144397114 hasAuthorship W2144397114A5022166327 @default.
• W2144397114 hasAuthorship W2144397114A5024673892 @default.
• W2144397114 hasAuthorship W2144397114A5031953660 @default.
• W2144397114 hasAuthorship W2144397114A5035235955 @default.
• W2144397114 hasAuthorship W2144397114A5042744407 @default.
• W2144397114 hasAuthorship W2144397114A5052597944 @default.
• W2144397114 hasAuthorship W2144397114A5056694857 @default.
• W2144397114 hasAuthorship W2144397114A5063900505 @default.
• W2144397114 hasAuthorship W2144397114A5069353507 @default.
• W2144397114 hasBestOaLocation W21443971141 @default.
• W2144397114 hasConcept C126322002 @default.
• W2144397114 hasConcept C134018914 @default.
• W2144397114 hasConcept C150903083 @default.
• W2144397114 hasConcept C185592680 @default.
• W2144397114 hasConcept C190283241 @default.
• W2144397114 hasConcept C207001950 @default.
• W2144397114 hasConcept C2778367456 @default.
• W2144397114 hasConcept C2778506107 @default.
• W2144397114 hasConcept C2779922275 @default.
• W2144397114 hasConcept C55493867 @default.
• W2144397114 hasConcept C555293320 @default.
• W2144397114 hasConcept C71924100 @default.
• W2144397114 hasConcept C86803240 @default.
• W2144397114 hasConceptScore W2144397114C126322002 @default.
• W2144397114 hasConceptScore W2144397114C134018914 @default.
• W2144397114 hasConceptScore W2144397114C150903083 @default.
• W2144397114 hasConceptScore W2144397114C185592680 @default.
• W2144397114 hasConceptScore W2144397114C190283241 @default.
• W2144397114 hasConceptScore W2144397114C207001950 @default.
• W2144397114 hasConceptScore W2144397114C2778367456 @default.
• W2144397114 hasConceptScore W2144397114C2778506107 @default.
• W2144397114 hasConceptScore W2144397114C2779922275 @default.
• W2144397114 hasConceptScore W2144397114C55493867 @default.
• W2144397114 hasConceptScore W2144397114C555293320 @default.
• W2144397114 hasConceptScore W2144397114C71924100 @default.
• W2144397114 hasConceptScore W2144397114C86803240 @default.

• next