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• W2144401377 endingPage "740" @default.
• W2144401377 startingPage "735" @default.
• W2144401377 abstract "ABSTRACT XRCC1 protein is essential for viability in mammals and is required for efficient DNA single-strand break repair and genetic stability following DNA base damage. We report here that XRCC1-dependent strand break repair in G 1 phase of the cell cycle is abolished by mutations created within the XRCC1 BRCT domain that interact with DNA ligase III. In contrast, XRCC1-dependent DNA strand break repair in S phase is largely unaffected by these mutations. These data describe a cell cycle-specific role for a BRCT domain, and we conclude that the XRCC1-DNA ligase III complex is required for DNA strand break repair in G 1 phase of the cell cycle but is dispensable for this process in S phase. The S-phase DNA repair process can remove both strand breaks induced in S phase and those that persist from G 1 and can in part compensate for lack of repair in G 1 . This process correlates with the appearance of XRCC1 nuclear foci that colocalize with Rad51 and may thus function in concert with homologous recombination." @default.
• W2144401377 created "2016-06-24" @default.
• W2144401377 creator A5024056651 @default.
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• W2144401377 creator A5077130187 @default.
• W2144401377 creator A5086570111 @default.
• W2144401377 date "2000-01-15" @default.
• W2144401377 modified "2023-10-16" @default.
• W2144401377 title "A Cell Cycle-Specific Requirement for the XRCC1 BRCT II Domain during Mammalian DNA Strand Break Repair" @default.
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• W2144401377 doi "https://doi.org/10.1128/mcb.20.2.735-740.2000" @default.
• W2144401377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/85188" @default.
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