Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144403602> ?p ?o ?g. }
- W2144403602 endingPage "144" @default.
- W2144403602 startingPage "135" @default.
- W2144403602 abstract "The two-component system PhoP/PhoQ controls a large number of genes responsible for a variety of physiological and virulence functions in Salmonella enterica serovar Typhimurium. Here we describe a mechanism whereby the transcriptional activator PhoP elicits expression of dissimilar gene sets when its cognate sensor PhoQ is activated by different signals in the periplasm. We determine that full transcription of over half of the genes directly activated by PhoP requires the Mg(2+) transporter MgtA when the PhoQ inducing signal is low Mg(2+) , but not when PhoQ is activated by mildly acidic pH or the antimicrobial peptide C18G. MgtA promotes the active (i.e. phosphorylated) form of PhoP by removing Mg(2+) from the periplasm, where it functions as a repressing signal for PhoQ. MgtA-dependent expression enhances resistance to the cationic antibiotic polymyxin B. Production of the MgtA protein requires cytoplasmic Mg(2+) levels to drop below a certain threshold, thereby creating a two-tiered temporal response among PhoP-dependent genes." @default.
- W2144403602 created "2016-06-24" @default.
- W2144403602 creator A5006670935 @default.
- W2144403602 creator A5063545607 @default.
- W2144403602 date "2013-11-20" @default.
- W2144403602 modified "2023-10-14" @default.
- W2144403602 title "Signal‐specific temporal response by the <i><scp>S</scp>almonella</i> <scp>PhoP</scp>/<scp>PhoQ</scp> regulatory system" @default.
- W2144403602 cites W1506313723 @default.
- W2144403602 cites W1525087137 @default.
- W2144403602 cites W1536743458 @default.
- W2144403602 cites W1568314805 @default.
- W2144403602 cites W1577239482 @default.
- W2144403602 cites W1969077183 @default.
- W2144403602 cites W1971469434 @default.
- W2144403602 cites W1972628407 @default.
- W2144403602 cites W1982760680 @default.
- W2144403602 cites W1985260825 @default.
- W2144403602 cites W1992717202 @default.
- W2144403602 cites W1993587759 @default.
- W2144403602 cites W2000566667 @default.
- W2144403602 cites W2005550545 @default.
- W2144403602 cites W2007152485 @default.
- W2144403602 cites W2008407072 @default.
- W2144403602 cites W2011903713 @default.
- W2144403602 cites W2016177577 @default.
- W2144403602 cites W2025539475 @default.
- W2144403602 cites W2025822882 @default.
- W2144403602 cites W2029578171 @default.
- W2144403602 cites W2034541624 @default.
- W2144403602 cites W2036772502 @default.
- W2144403602 cites W2038540528 @default.
- W2144403602 cites W2038803168 @default.
- W2144403602 cites W2052205534 @default.
- W2144403602 cites W2056618449 @default.
- W2144403602 cites W2058473414 @default.
- W2144403602 cites W2065977531 @default.
- W2144403602 cites W2075026718 @default.
- W2144403602 cites W2080135618 @default.
- W2144403602 cites W2083128576 @default.
- W2144403602 cites W2091813080 @default.
- W2144403602 cites W2099498225 @default.
- W2144403602 cites W2116732603 @default.
- W2144403602 cites W2118745005 @default.
- W2144403602 cites W2121665468 @default.
- W2144403602 cites W2121708506 @default.
- W2144403602 cites W2123152720 @default.
- W2144403602 cites W2123374042 @default.
- W2144403602 cites W2124485275 @default.
- W2144403602 cites W2140324276 @default.
- W2144403602 cites W2145552975 @default.
- W2144403602 cites W2147680302 @default.
- W2144403602 cites W2155627295 @default.
- W2144403602 cites W2157217625 @default.
- W2144403602 cites W2160170449 @default.
- W2144403602 cites W2162416324 @default.
- W2144403602 cites W2165202736 @default.
- W2144403602 cites W2169621668 @default.
- W2144403602 doi "https://doi.org/10.1111/mmi.12449" @default.
- W2144403602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3890429" @default.
- W2144403602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24256574" @default.
- W2144403602 hasPublicationYear "2013" @default.
- W2144403602 type Work @default.
- W2144403602 sameAs 2144403602 @default.
- W2144403602 citedByCount "53" @default.
- W2144403602 countsByYear W21444036022015 @default.
- W2144403602 countsByYear W21444036022016 @default.
- W2144403602 countsByYear W21444036022017 @default.
- W2144403602 countsByYear W21444036022018 @default.
- W2144403602 countsByYear W21444036022019 @default.
- W2144403602 countsByYear W21444036022020 @default.
- W2144403602 countsByYear W21444036022021 @default.
- W2144403602 countsByYear W21444036022022 @default.
- W2144403602 countsByYear W21444036022023 @default.
- W2144403602 crossrefType "journal-article" @default.
- W2144403602 hasAuthorship W2144403602A5006670935 @default.
- W2144403602 hasAuthorship W2144403602A5063545607 @default.
- W2144403602 hasBestOaLocation W21444036021 @default.
- W2144403602 hasConcept C104317684 @default.
- W2144403602 hasConcept C10858879 @default.
- W2144403602 hasConcept C138885662 @default.
- W2144403602 hasConcept C150194340 @default.
- W2144403602 hasConcept C167625842 @default.
- W2144403602 hasConcept C179926584 @default.
- W2144403602 hasConcept C201663137 @default.
- W2144403602 hasConcept C2779607309 @default.
- W2144403602 hasConcept C41895202 @default.
- W2144403602 hasConcept C547475151 @default.
- W2144403602 hasConcept C55493867 @default.
- W2144403602 hasConcept C60987743 @default.
- W2144403602 hasConcept C86339819 @default.
- W2144403602 hasConcept C86803240 @default.
- W2144403602 hasConcept C89423630 @default.
- W2144403602 hasConcept C95444343 @default.
- W2144403602 hasConceptScore W2144403602C104317684 @default.
- W2144403602 hasConceptScore W2144403602C10858879 @default.
- W2144403602 hasConceptScore W2144403602C138885662 @default.
- W2144403602 hasConceptScore W2144403602C150194340 @default.
- W2144403602 hasConceptScore W2144403602C167625842 @default.