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- W2144405910 abstract "Abstract The genome of Schizosaccharomyces pombe contains five genes that code for proteins with sequence similarity to the Escherichia coli recombination protein RecA: rad51+, rhp55+, rhp57+, rlp1+, and dmc1+. We analyzed the effect of deletion of each of these genes on meiotic recombination and viability of spores. Meiotic recombination levels were different from wild type in all recA-related mutants in several genetic intervals, suggesting that all five RecA homologs of S. pombe are required for normal levels of meiotic recombination. Spore viability was reduced in rad51, rhp55, and rhp57 mutants, but not in rlp1 and dmc1. It is argued that reduction of crossover is not the only cause for the observed reduction of spore viability. Analysis of double and triple mutants revealed that Rad51 and Dmc1 play major and partially overlapping roles in meiotic recombination, while Rhp55, Rhp57, and Rlp1 play accessory roles. Remarkably, deletion of Rlp1 decreases the frequency of intergenic recombination (crossovers), but increases intragenic recombination (gene conversion). On the basis of our results, we present a model for the involvement of five RecA-like proteins of S. pombe in meiotic recombination and discuss their respective roles." @default.
- W2144405910 created "2016-06-24" @default.
- W2144405910 creator A5000828582 @default.
- W2144405910 creator A5073824397 @default.
- W2144405910 date "2003-11-01" @default.
- W2144405910 modified "2023-10-11" @default.
- W2144405910 title "Five RecA-like Proteins of <i>Schizosaccharomyces pombe</i> Are Involved in Meiotic Recombination" @default.
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- W2144405910 doi "https://doi.org/10.1093/genetics/165.3.1031" @default.
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