FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144408553> ?p ?o ?g. }

• W2144408553 endingPage "e1003591" @default.
• W2144408553 startingPage "e1003591" @default.
• W2144408553 abstract "The 3′ untranslated genome region (UTR) of arthropod-borne viruses is characterized by enriched direct repeats (DRs) and stem-loop structures. Despite many years of theoretical and experimental study, on-going positive selection on the 3′UTR had never been observed in ‘real-time,’ and the role of the arbovirus 3′UTR remains poorly understood. We observed a lineage-specific 3′UTR sequence pattern in all available Asian lineage of the mosquito-borne alphavirus, chikungunya virus (CHIKV) (1958–2009), including complicated mutation and duplication patterns of the long DRs. Given that a longer genome is usually associated with less efficient replication, we hypothesized that the fixation of these genetic changes in the Asian lineage 3′UTR was due to their beneficial effects on adaptation to vectors or hosts. Using reverse genetic methods, we examined the functional importance of each direct repeat. Our results suggest that adaptation to mosquitoes, rather than to mammalian hosts, is a major evolutionary force on the CHIKV 3′UTR. Surprisingly, the Asian 3′UTR appeared to be inferior to its predicted ancestral sequence for replication in both mammals and mosquitoes, suggesting that its fixation in Asia was not a result of directional selection. Rather, it may have resulted from a population bottleneck during its introduction from Africa to Asia. We propose that this introduction of a 3′UTR with deletions led to genetic drift and compensatory mutations associated with the loss of structural/functional constraints, followed by two independent beneficial duplications and fixation due to positive selection. Our results provide further evidence that the limited epidemic potential of the Asian CHIKV strains resulted from founder effects that reduced its fitness for efficient transmission by mosquitoes there." @default.
• W2144408553 created "2016-06-24" @default.
• W2144408553 creator A5013244749 @default.
• W2144408553 creator A5047747076 @default.
• W2144408553 creator A5076561442 @default.
• W2144408553 creator A5084312345 @default.
• W2144408553 date "2013-08-29" @default.
• W2144408553 modified "2023-10-12" @default.
• W2144408553 title "Chikungunya Virus 3′ Untranslated Region: Adaptation to Mosquitoes and a Population Bottleneck as Major Evolutionary Forces" @default.
• W2144408553 cites W118013854 @default.
• W2144408553 cites W1591665016 @default.
• W2144408553 cites W1756899047 @default.
• W2144408553 cites W1808156524 @default.
• W2144408553 cites W1816614902 @default.
• W2144408553 cites W1830896867 @default.
• W2144408553 cites W1983944220 @default.
• W2144408553 cites W1988402786 @default.
• W2144408553 cites W1992173694 @default.
• W2144408553 cites W2008401094 @default.
• W2144408553 cites W2009736453 @default.
• W2144408553 cites W2010444790 @default.
• W2144408553 cites W2011367808 @default.
• W2144408553 cites W2013958983 @default.
• W2144408553 cites W2026925011 @default.
• W2144408553 cites W2029116599 @default.
• W2144408553 cites W2032928481 @default.
• W2144408553 cites W2038594218 @default.
• W2144408553 cites W2049285992 @default.
• W2144408553 cites W2052505961 @default.
• W2144408553 cites W2062504884 @default.
• W2144408553 cites W2064420690 @default.
• W2144408553 cites W2065843293 @default.
• W2144408553 cites W2066118404 @default.
• W2144408553 cites W2070179005 @default.
• W2144408553 cites W2075702353 @default.
• W2144408553 cites W2082928585 @default.
• W2144408553 cites W2097212976 @default.
• W2144408553 cites W2097867274 @default.
• W2144408553 cites W2101221024 @default.
• W2144408553 cites W2103900038 @default.
• W2144408553 cites W2104898502 @default.
• W2144408553 cites W2105538224 @default.
• W2144408553 cites W2111272410 @default.
• W2144408553 cites W2111395315 @default.
• W2144408553 cites W2118614072 @default.
• W2144408553 cites W2119638322 @default.
• W2144408553 cites W2120666343 @default.
• W2144408553 cites W2122278014 @default.
• W2144408553 cites W2125716576 @default.
• W2144408553 cites W2127003764 @default.
• W2144408553 cites W2129622364 @default.
• W2144408553 cites W2130852847 @default.
• W2144408553 cites W2134015165 @default.
• W2144408553 cites W2139749370 @default.
• W2144408553 cites W2141157874 @default.
• W2144408553 cites W2149562859 @default.
• W2144408553 cites W2152305184 @default.
• W2144408553 cites W2156205184 @default.
• W2144408553 cites W2157483415 @default.
• W2144408553 cites W2159356412 @default.
• W2144408553 cites W2159379501 @default.
• W2144408553 cites W2162081672 @default.
• W2144408553 cites W2163478597 @default.
• W2144408553 cites W2172029742 @default.
• W2144408553 cites W2172291230 @default.
• W2144408553 doi "https://doi.org/10.1371/journal.ppat.1003591" @default.
• W2144408553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3757053" @default.
• W2144408553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24009512" @default.
• W2144408553 hasPublicationYear "2013" @default.
• W2144408553 type Work @default.
• W2144408553 sameAs 2144408553 @default.
• W2144408553 citedByCount "78" @default.
• W2144408553 countsByYear W21444085532014 @default.
• W2144408553 countsByYear W21444085532015 @default.
• W2144408553 countsByYear W21444085532016 @default.
• W2144408553 countsByYear W21444085532017 @default.
• W2144408553 countsByYear W21444085532018 @default.
• W2144408553 countsByYear W21444085532019 @default.
• W2144408553 countsByYear W21444085532020 @default.
• W2144408553 countsByYear W21444085532021 @default.
• W2144408553 countsByYear W21444085532022 @default.
• W2144408553 countsByYear W21444085532023 @default.
• W2144408553 crossrefType "journal-article" @default.
• W2144408553 hasAuthorship W2144408553A5013244749 @default.
• W2144408553 hasAuthorship W2144408553A5047747076 @default.
• W2144408553 hasAuthorship W2144408553A5076561442 @default.
• W2144408553 hasAuthorship W2144408553A5084312345 @default.
• W2144408553 hasBestOaLocation W21444085531 @default.
• W2144408553 hasConcept C104317684 @default.
• W2144408553 hasConcept C105076106 @default.
• W2144408553 hasConcept C12464233 @default.
• W2144408553 hasConcept C144024400 @default.
• W2144408553 hasConcept C149923435 @default.
• W2144408553 hasConcept C159047783 @default.
• W2144408553 hasConcept C180754005 @default.
• W2144408553 hasConcept C22667442 @default.
• W2144408553 hasConcept C2522874641 @default.
• W2144408553 hasConcept C2776817793 @default.

• next