FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144411376> ?p ?o ?g. }

• W2144411376 endingPage "2398" @default.
• W2144411376 startingPage "2392" @default.
• W2144411376 abstract "To characterize the impact of graft T-cell composition on outcomes of reduced-intensity conditioned (RIC) allogeneic hematopoietic stem-cell transplantation (alloHSCT) in adults with hematologic malignancies.We evaluated associations between graft T-cell doses and outcomes in 200 patients who underwent RIC alloHSCT with a peripheral blood stem-cell graft. We then studied 21 alloHSCT donors to identify predictors of optimal graft T-cell content.Higher CD8 cell doses were associated with a lower risk for relapse (adjusted hazard ratio [aHR], 0.43; P = .009) and improved relapse-free survival (aHR, 0.50; P = .006) and overall survival (aHR, 0.57; P = .04) without a significant increase in graft-versus-host disease or nonrelapse mortality. A cutoff level of 0.72 × 10(8) CD8 cells per kilogram optimally segregated patients receiving CD8(hi) and CD8(lo) grafts with differing overall survival (P = .007). Donor age inversely correlated with graft CD8 dose. Consequently, older donors were unlikely to provide a CD8(hi) graft, whereas approximately half of younger donors provided CD8(hi) grafts. Compared with recipients of older sibling donor grafts (consistently containing CD8(lo) doses), survival was significantly better for recipients of younger unrelated donor grafts with CD8(hi) doses (P = .03), but not for recipients of younger unrelated donor CD8(lo) grafts (P = .28). In addition, graft CD8 content could be predicted by measuring the proportion of CD8 cells in a screening blood sample from stem-cell donors.Higher graft CD8 dose, which was restricted to young donors, predicted better survival in patients undergoing RIC alloHSCT." @default.
• W2144411376 created "2016-06-24" @default.
• W2144411376 creator A5014111069 @default.
• W2144411376 creator A5014838335 @default.
• W2144411376 creator A5023287139 @default.
• W2144411376 creator A5023296232 @default.
• W2144411376 creator A5029801761 @default.
• W2144411376 creator A5037534938 @default.
• W2144411376 creator A5039491957 @default.
• W2144411376 creator A5040750947 @default.
• W2144411376 creator A5041976525 @default.
• W2144411376 creator A5052264374 @default.
• W2144411376 creator A5065936059 @default.
• W2144411376 creator A5079773324 @default.
• W2144411376 creator A5085167557 @default.
• W2144411376 creator A5085195242 @default.
• W2144411376 creator A5088286702 @default.
• W2144411376 creator A5089409657 @default.
• W2144411376 creator A5091612581 @default.
• W2144411376 creator A5091661654 @default.
• W2144411376 date "2015-07-20" @default.
• W2144411376 modified "2023-10-18" @default.
• W2144411376 title "High Graft CD8 Cell Dose Predicts Improved Survival and Enables Better Donor Selection in Allogeneic Stem-Cell Transplantation With Reduced-Intensity Conditioning" @default.
• W2144411376 cites W1491993932 @default.
• W2144411376 cites W1510545292 @default.
• W2144411376 cites W1604668557 @default.
• W2144411376 cites W1963723988 @default.
• W2144411376 cites W1978164777 @default.
• W2144411376 cites W1987350756 @default.
• W2144411376 cites W1994075039 @default.
• W2144411376 cites W2006427551 @default.
• W2144411376 cites W2016967633 @default.
• W2144411376 cites W2017978806 @default.
• W2144411376 cites W2024691638 @default.
• W2144411376 cites W2027090443 @default.
• W2144411376 cites W2028815852 @default.
• W2144411376 cites W2032541332 @default.
• W2144411376 cites W2055444881 @default.
• W2144411376 cites W2056006514 @default.
• W2144411376 cites W2058256886 @default.
• W2144411376 cites W2064085613 @default.
• W2144411376 cites W2068160300 @default.
• W2144411376 cites W2072435923 @default.
• W2144411376 cites W2074326274 @default.
• W2144411376 cites W2074637790 @default.
• W2144411376 cites W2090519409 @default.
• W2144411376 cites W2090761813 @default.
• W2144411376 cites W2095746947 @default.
• W2144411376 cites W2096254625 @default.
• W2144411376 cites W2099413806 @default.
• W2144411376 cites W2109686908 @default.
• W2144411376 cites W2111717354 @default.
• W2144411376 cites W2131485909 @default.
• W2144411376 cites W2138198874 @default.
• W2144411376 cites W2140143467 @default.
• W2144411376 cites W2151704978 @default.
• W2144411376 cites W2169668771 @default.
• W2144411376 cites W2379365975 @default.
• W2144411376 cites W2618073389 @default.
• W2144411376 doi "https://doi.org/10.1200/jco.2014.60.1203" @default.
• W2144411376 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4500833" @default.
• W2144411376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26056179" @default.
• W2144411376 hasPublicationYear "2015" @default.
• W2144411376 type Work @default.
• W2144411376 sameAs 2144411376 @default.
• W2144411376 citedByCount "48" @default.
• W2144411376 countsByYear W21444113762015 @default.
• W2144411376 countsByYear W21444113762016 @default.
• W2144411376 countsByYear W21444113762017 @default.
• W2144411376 countsByYear W21444113762018 @default.
• W2144411376 countsByYear W21444113762019 @default.
• W2144411376 countsByYear W21444113762020 @default.
• W2144411376 countsByYear W21444113762021 @default.
• W2144411376 countsByYear W21444113762022 @default.
• W2144411376 countsByYear W21444113762023 @default.
• W2144411376 crossrefType "journal-article" @default.
• W2144411376 hasAuthorship W2144411376A5014111069 @default.
• W2144411376 hasAuthorship W2144411376A5014838335 @default.
• W2144411376 hasAuthorship W2144411376A5023287139 @default.
• W2144411376 hasAuthorship W2144411376A5023296232 @default.
• W2144411376 hasAuthorship W2144411376A5029801761 @default.
• W2144411376 hasAuthorship W2144411376A5037534938 @default.
• W2144411376 hasAuthorship W2144411376A5039491957 @default.
• W2144411376 hasAuthorship W2144411376A5040750947 @default.
• W2144411376 hasAuthorship W2144411376A5041976525 @default.
• W2144411376 hasAuthorship W2144411376A5052264374 @default.
• W2144411376 hasAuthorship W2144411376A5065936059 @default.
• W2144411376 hasAuthorship W2144411376A5079773324 @default.
• W2144411376 hasAuthorship W2144411376A5085167557 @default.
• W2144411376 hasAuthorship W2144411376A5085195242 @default.
• W2144411376 hasAuthorship W2144411376A5088286702 @default.
• W2144411376 hasAuthorship W2144411376A5089409657 @default.
• W2144411376 hasAuthorship W2144411376A5091612581 @default.
• W2144411376 hasAuthorship W2144411376A5091661654 @default.
• W2144411376 hasBestOaLocation W21444113761 @default.
• W2144411376 hasConcept C126322002 @default.
• W2144411376 hasConcept C143998085 @default.
• W2144411376 hasConcept C154317977 @default.

• next