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- W2144429477 abstract "In patients with cirrhosis, increased intrahepatic vascular resistance and portal blood flow contribute to the development of portal hypertension and its complications.1Accordingly, the goal of pharmacological treatment is to reduce portal pressure and thus variceal pressure. This beneficial effect may be obtained by decreasing portal blood flow or intrahepatic vascular resistance, or both. Certain drugs cause splanchnic vasoconstriction and thus reduce portal blood flow and portal pressure and others cause intrahepatic vasodilatation and thus reduce intrahepatic vascular resistance and portal pressure (table 1). The mechanisms of action of certain portal hypotensive drugs have not been clarified. View this table:Table 1 Portal hypotensive drugs The occurrence of ruptured varices is not directly correlated with the degree of portal hypertension2 but clinical studies have shown that a reduction in portal pressure decreases the risk of bleeding and can …" @default.
- W2144429477 created "2016-06-24" @default.
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- W2144429477 date "2001-09-01" @default.
- W2144429477 modified "2023-09-23" @default.
- W2144429477 title "Drug therapy for portal hypertension." @default.
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- W2144429477 doi "https://doi.org/10.1136/gut.49.3.441" @default.
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