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- W2144454014 abstract "The premutation of the FMR1 gene (defined as between 55 and 200 CGG repeats) is estimated to affect 1 in 149 females and 1 in 643 males, and some people who carry the FMR1 premutation display signs of impairment.This study focuses on 82 premutation carrier mothers (M age = 51.4 years; SD = 7.7) of adolescent and adult children with fragile X syndrome (FXS). A Gene × Environment interaction approach examined the ways in which the experience of negative life events interacts with genetic vulnerability to predict depressive symptoms, anxiety, and daily cortisol levels.The associations of life events with all 3 dependent measures were associated with CGG repeat length but in a curvilinear manner. Mothers with midsize CGG repeats who experienced above-average numbers of negative life events in the previous year had more depressive symptoms and anxiety and had a blunted cortisol awakening response, as compared with those with higher or lower repeat lengths. However, mothers with midsize CGG repeats who experienced below-average numbers of negative life events in the previous year had the lowest levels of depressive symptoms and anxiety, and they exhibited the typical cortisol response to awakening, meeting the criteria for differential susceptibility.This research extends our understanding of the phenotypic effects of the expansion of the FMR1 gene, and it adds to the growing literature on the curvilinear relationship between CGG repeat length and mental and physical health." @default.
- W2144454014 created "2016-06-24" @default.
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- W2144454014 date "2012-01-01" @default.
- W2144454014 modified "2023-09-29" @default.
- W2144454014 title "Differential sensitivity to life stress in FMR1 premutation carrier mothers of children with Fragile X Syndrome." @default.
- W2144454014 cites W1486091068 @default.
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- W2144454014 cites W1968787277 @default.
- W2144454014 cites W1970260137 @default.
- W2144454014 cites W1977143695 @default.
- W2144454014 cites W1985166802 @default.
- W2144454014 cites W1990220949 @default.
- W2144454014 cites W1997941464 @default.
- W2144454014 cites W2011044338 @default.
- W2144454014 cites W2013102688 @default.
- W2144454014 cites W2013621624 @default.
- W2144454014 cites W2038561863 @default.
- W2144454014 cites W2039453659 @default.
- W2144454014 cites W2040316692 @default.
- W2144454014 cites W2041086236 @default.
- W2144454014 cites W2044502398 @default.
- W2144454014 cites W2050703831 @default.
- W2144454014 cites W2051559684 @default.
- W2144454014 cites W2063341153 @default.
- W2144454014 cites W2066023299 @default.
- W2144454014 cites W2067664488 @default.
- W2144454014 cites W2071271451 @default.
- W2144454014 cites W2074299340 @default.
- W2144454014 cites W2077568976 @default.
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- W2144454014 cites W2082509348 @default.
- W2144454014 cites W2088613953 @default.
- W2144454014 cites W2089950914 @default.
- W2144454014 cites W2091413411 @default.
- W2144454014 cites W2095006822 @default.
- W2144454014 cites W2097506358 @default.
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- W2144454014 cites W2103118063 @default.
- W2144454014 cites W2103768332 @default.
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- W2144454014 cites W2117837844 @default.
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- W2144454014 cites W2122660231 @default.
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- W2144454014 doi "https://doi.org/10.1037/a0026528" @default.
- W2144454014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3434309" @default.
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