FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144455387> ?p ?o ?g. }

• W2144455387 endingPage "638" @default.
• W2144455387 startingPage "629" @default.
• W2144455387 abstract "Maintenance of genome integrity is of critical importance to cells. To identify key regulators of genomic integrity, we screened a human cell line with a kinome small interfering RNA library. WEE1, a major regulator of mitotic entry, and CHK1 were among the genes identified. Both kinases are important negative regulators of CDK1 and -2. Strikingly, WEE1 depletion rapidly induced DNA damage in S phase in newly replicated DNA, which was accompanied by a marked increase in single-stranded DNA. This DNA damage is dependent on CDK1 and -2 as well as the replication proteins MCM2 and CDT1 but not CDC25A. Conversely, DNA damage after CHK1 inhibition is highly dependent on CDC25A. Furthermore, the inferior proliferation of CHK1-depleted cells is improved substantially by codepletion of CDC25A. We conclude that the mitotic kinase WEE1 and CHK1 jointly maintain balanced cellular control of Cdk activity during normal DNA replication, which is crucial to prevent the generation of harmful DNA lesions during replication." @default.
• W2144455387 created "2016-06-24" @default.
• W2144455387 creator A5001825731 @default.
• W2144455387 creator A5016923180 @default.
• W2144455387 creator A5029296072 @default.
• W2144455387 creator A5031321141 @default.
• W2144455387 creator A5063817650 @default.
• W2144455387 creator A5064887247 @default.
• W2144455387 creator A5084114891 @default.
• W2144455387 creator A5085915404 @default.
• W2144455387 creator A5086261240 @default.
• W2144455387 creator A5088245919 @default.
• W2144455387 date "2010-03-01" @default.
• W2144455387 modified "2023-10-04" @default.
• W2144455387 title "Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase" @default.
• W2144455387 cites W1965239527 @default.
• W2144455387 cites W1965629601 @default.
• W2144455387 cites W1986707765 @default.
• W2144455387 cites W1988280121 @default.
• W2144455387 cites W2006220656 @default.
• W2144455387 cites W2010051771 @default.
• W2144455387 cites W2013714072 @default.
• W2144455387 cites W2023512697 @default.
• W2144455387 cites W2024235347 @default.
• W2144455387 cites W2035300822 @default.
• W2144455387 cites W2038340312 @default.
• W2144455387 cites W2041156660 @default.
• W2144455387 cites W2045489863 @default.
• W2144455387 cites W2064558160 @default.
• W2144455387 cites W2086333179 @default.
• W2144455387 cites W2116964110 @default.
• W2144455387 cites W2117213589 @default.
• W2144455387 cites W2121371748 @default.
• W2144455387 cites W2124585743 @default.
• W2144455387 cites W2149795092 @default.
• W2144455387 cites W2154421320 @default.
• W2144455387 cites W2159203162 @default.
• W2144455387 cites W2159675211 @default.
• W2144455387 cites W4255855797 @default.
• W2144455387 doi "https://doi.org/10.1083/jcb.200905059" @default.
• W2144455387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2835936" @default.
• W2144455387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20194642" @default.
• W2144455387 hasPublicationYear "2010" @default.
• W2144455387 type Work @default.
• W2144455387 sameAs 2144455387 @default.
• W2144455387 citedByCount "144" @default.
• W2144455387 countsByYear W21444553872012 @default.
• W2144455387 countsByYear W21444553872013 @default.
• W2144455387 countsByYear W21444553872014 @default.
• W2144455387 countsByYear W21444553872015 @default.
• W2144455387 countsByYear W21444553872016 @default.
• W2144455387 countsByYear W21444553872017 @default.
• W2144455387 countsByYear W21444553872018 @default.
• W2144455387 countsByYear W21444553872019 @default.
• W2144455387 countsByYear W21444553872020 @default.
• W2144455387 countsByYear W21444553872021 @default.
• W2144455387 countsByYear W21444553872022 @default.
• W2144455387 countsByYear W21444553872023 @default.
• W2144455387 crossrefType "journal-article" @default.
• W2144455387 hasAuthorship W2144455387A5001825731 @default.
• W2144455387 hasAuthorship W2144455387A5016923180 @default.
• W2144455387 hasAuthorship W2144455387A5029296072 @default.
• W2144455387 hasAuthorship W2144455387A5031321141 @default.
• W2144455387 hasAuthorship W2144455387A5063817650 @default.
• W2144455387 hasAuthorship W2144455387A5064887247 @default.
• W2144455387 hasAuthorship W2144455387A5084114891 @default.
• W2144455387 hasAuthorship W2144455387A5085915404 @default.
• W2144455387 hasAuthorship W2144455387A5086261240 @default.
• W2144455387 hasAuthorship W2144455387A5088245919 @default.
• W2144455387 hasBestOaLocation W21444553871 @default.
• W2144455387 hasConcept C104317684 @default.
• W2144455387 hasConcept C104690221 @default.
• W2144455387 hasConcept C105696609 @default.
• W2144455387 hasConcept C120504264 @default.
• W2144455387 hasConcept C124320809 @default.
• W2144455387 hasConcept C134935766 @default.
• W2144455387 hasConcept C143425029 @default.
• W2144455387 hasConcept C175193931 @default.
• W2144455387 hasConcept C178169997 @default.
• W2144455387 hasConcept C184235292 @default.
• W2144455387 hasConcept C2781252693 @default.
• W2144455387 hasConcept C29537977 @default.
• W2144455387 hasConcept C50001416 @default.
• W2144455387 hasConcept C54086632 @default.
• W2144455387 hasConcept C54174078 @default.
• W2144455387 hasConcept C54355233 @default.
• W2144455387 hasConcept C552990157 @default.
• W2144455387 hasConcept C67419583 @default.
• W2144455387 hasConcept C73573662 @default.
• W2144455387 hasConcept C86803240 @default.
• W2144455387 hasConcept C93304396 @default.
• W2144455387 hasConcept C95444343 @default.
• W2144455387 hasConcept C98086919 @default.
• W2144455387 hasConceptScore W2144455387C104317684 @default.
• W2144455387 hasConceptScore W2144455387C104690221 @default.
• W2144455387 hasConceptScore W2144455387C105696609 @default.
• W2144455387 hasConceptScore W2144455387C120504264 @default.
• W2144455387 hasConceptScore W2144455387C124320809 @default.

• next