Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144500560> ?p ?o ?g. }
- W2144500560 endingPage "350" @default.
- W2144500560 startingPage "335" @default.
- W2144500560 abstract "The Fc receptors (FcRs) and their interactions with immunoglobulin and innate immune opsonins, such as C-reactive protein, are key players in humoral and cellular immune responses. As the effector mechanism for some therapeutic monoclonal antibodies, and often a contributor to the pathogenesis and progression of autoimmunity, FcRs are promising targets for treating autoimmune diseases.This review discusses the nature of different FcRs and the various mechanisms of their involvement in initiating and modulating immunocyte functions and their biological consequences. It describes a range of current strategies in targeting FcRs and manipulating their interaction with specific ligands, while presenting the pros and cons of these approaches. This review also discusses potential new strategies including regulation of FcR expression and receptor crosstalk.FcRs are appealing targets in the treatment of inflammatory autoimmune diseases. However, there are still knowledge limitations and technical challenges, the most important being a better understanding of the individual roles of each of the FcRs and enhancement of the specificity in targeting particular cell types and specific FcRs." @default.
- W2144500560 created "2016-06-24" @default.
- W2144500560 creator A5000991634 @default.
- W2144500560 creator A5007576322 @default.
- W2144500560 date "2014-02-13" @default.
- W2144500560 modified "2023-10-03" @default.
- W2144500560 title "Targeting the Fc receptor in autoimmune disease" @default.
- W2144500560 cites W1493742659 @default.
- W2144500560 cites W1509314368 @default.
- W2144500560 cites W1518819083 @default.
- W2144500560 cites W1520693665 @default.
- W2144500560 cites W1530340727 @default.
- W2144500560 cites W1530344826 @default.
- W2144500560 cites W1545229471 @default.
- W2144500560 cites W1559928694 @default.
- W2144500560 cites W1565880338 @default.
- W2144500560 cites W1589948586 @default.
- W2144500560 cites W1671219112 @default.
- W2144500560 cites W1768700520 @default.
- W2144500560 cites W1871780345 @default.
- W2144500560 cites W1903287340 @default.
- W2144500560 cites W1926541123 @default.
- W2144500560 cites W1961162988 @default.
- W2144500560 cites W1964180982 @default.
- W2144500560 cites W1965962344 @default.
- W2144500560 cites W1968047763 @default.
- W2144500560 cites W1969926626 @default.
- W2144500560 cites W1975039969 @default.
- W2144500560 cites W1976843984 @default.
- W2144500560 cites W1979162895 @default.
- W2144500560 cites W1979336667 @default.
- W2144500560 cites W1982880308 @default.
- W2144500560 cites W1983840607 @default.
- W2144500560 cites W1985095860 @default.
- W2144500560 cites W1985200221 @default.
- W2144500560 cites W1986197388 @default.
- W2144500560 cites W1987880212 @default.
- W2144500560 cites W1989236531 @default.
- W2144500560 cites W1989529519 @default.
- W2144500560 cites W1990149403 @default.
- W2144500560 cites W1990868266 @default.
- W2144500560 cites W1991706567 @default.
- W2144500560 cites W1992507941 @default.
- W2144500560 cites W1994654686 @default.
- W2144500560 cites W1995250806 @default.
- W2144500560 cites W1999072281 @default.
- W2144500560 cites W2000137099 @default.
- W2144500560 cites W2000748318 @default.
- W2144500560 cites W2002496843 @default.
- W2144500560 cites W2004105065 @default.
- W2144500560 cites W2004756723 @default.
- W2144500560 cites W2009598751 @default.
- W2144500560 cites W2009900556 @default.
- W2144500560 cites W2010329820 @default.
- W2144500560 cites W2011835274 @default.
- W2144500560 cites W2013517719 @default.
- W2144500560 cites W2015418566 @default.
- W2144500560 cites W2017014846 @default.
- W2144500560 cites W2017341404 @default.
- W2144500560 cites W2018522670 @default.
- W2144500560 cites W2025760628 @default.
- W2144500560 cites W2028672566 @default.
- W2144500560 cites W2028715633 @default.
- W2144500560 cites W2029993165 @default.
- W2144500560 cites W2030679171 @default.
- W2144500560 cites W2031321129 @default.
- W2144500560 cites W2032420547 @default.
- W2144500560 cites W2032874971 @default.
- W2144500560 cites W2033330205 @default.
- W2144500560 cites W2033647820 @default.
- W2144500560 cites W2033806521 @default.
- W2144500560 cites W2035433348 @default.
- W2144500560 cites W2037007095 @default.
- W2144500560 cites W2037932549 @default.
- W2144500560 cites W2038899919 @default.
- W2144500560 cites W2042797177 @default.
- W2144500560 cites W2043586796 @default.
- W2144500560 cites W2044360617 @default.
- W2144500560 cites W2045072103 @default.
- W2144500560 cites W2048259741 @default.
- W2144500560 cites W2052032023 @default.
- W2144500560 cites W2052746029 @default.
- W2144500560 cites W2054178734 @default.
- W2144500560 cites W2055465436 @default.
- W2144500560 cites W2056154690 @default.
- W2144500560 cites W2056462157 @default.
- W2144500560 cites W2058915223 @default.
- W2144500560 cites W2059105414 @default.
- W2144500560 cites W2061641422 @default.
- W2144500560 cites W2062526524 @default.
- W2144500560 cites W2063470653 @default.
- W2144500560 cites W2065869173 @default.
- W2144500560 cites W2066984389 @default.
- W2144500560 cites W2068916410 @default.
- W2144500560 cites W2069858985 @default.
- W2144500560 cites W2070900214 @default.
- W2144500560 cites W2071843728 @default.
- W2144500560 cites W2072086606 @default.