Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144504927> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2144504927 endingPage "1" @default.
- W2144504927 startingPage "1" @default.
- W2144504927 abstract "Sodium retention is a hallmark of nephrotic syndrome. We investigated whether sodium retention is associated with changes of natriuretic peptide system at different stages (i.e., a sodium retaining stage and a compensatory stage) of nephrotic syndrome. At day 7 after PAN (puromycin aminonucleoside) injection, the urinary excretion of sodium was decreased, along with the development of ascites and positive sodium balance. The plasma and urinary ANP (atrial natriuretic peptide) immunoreactivities were increased. ANP mRNA expression was increased in the heart and kidney, whereas that of NPR (natriuretic peptide receptor)-A and NPR-C mRNA was decreased in the kidney. The expression of NEP was decreased in the kidney. At day 14, urinary excretion of sodium did not differ from the control. The plasma ANP level and heart ANP mRNA expression returned to their control values. The expression of ANP mRNA in the kidney was increased in association with increased urinary ANP immunoreactivities. The expression of NPR-A in the kidney became normal, whereas that of NPR-C kept decreased. The expression of NEP (neutral endopeptidase) remained decreased. These findings suggest that the increased renal ANP synthesis in association with decreased metabolism via NEP and NPR-C may play a compensatory role against the development of sodium retention in nephrotic syndrome. The decreased of NPR-A expression in the kidney may contribute to the ANP resistance at day 7. The subsequent recovery of NPR-A expression may play a role in promoting sodium excretion in later stage (at day 14)." @default.
- W2144504927 created "2016-06-24" @default.
- W2144504927 creator A5044585468 @default.
- W2144504927 creator A5048321650 @default.
- W2144504927 creator A5049703409 @default.
- W2144504927 creator A5066474772 @default.
- W2144504927 date "2009-01-01" @default.
- W2144504927 modified "2023-10-18" @default.
- W2144504927 title "Changes of Atrial Natriuretic Peptide System in Rats with Puromycin Aminonucleoside-Induced Nephrotic Syndrome" @default.
- W2144504927 cites W1936780558 @default.
- W2144504927 cites W2000150016 @default.
- W2144504927 cites W2013989606 @default.
- W2144504927 cites W2021360010 @default.
- W2144504927 cites W2038101664 @default.
- W2144504927 cites W2041072526 @default.
- W2144504927 cites W2043463661 @default.
- W2144504927 cites W2071997038 @default.
- W2144504927 cites W2075521903 @default.
- W2144504927 cites W2107277218 @default.
- W2144504927 cites W2107765192 @default.
- W2144504927 cites W2117367934 @default.
- W2144504927 cites W2152804425 @default.
- W2144504927 cites W2155179688 @default.
- W2144504927 cites W2167187669 @default.
- W2144504927 cites W2410365184 @default.
- W2144504927 doi "https://doi.org/10.4196/kjpp.2009.13.1.1" @default.
- W2144504927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2766717" @default.
- W2144504927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19885019" @default.
- W2144504927 hasPublicationYear "2009" @default.
- W2144504927 type Work @default.
- W2144504927 sameAs 2144504927 @default.
- W2144504927 citedByCount "3" @default.
- W2144504927 countsByYear W21445049272013 @default.
- W2144504927 countsByYear W21445049272022 @default.
- W2144504927 crossrefType "journal-article" @default.
- W2144504927 hasAuthorship W2144504927A5044585468 @default.
- W2144504927 hasAuthorship W2144504927A5048321650 @default.
- W2144504927 hasAuthorship W2144504927A5049703409 @default.
- W2144504927 hasAuthorship W2144504927A5066474772 @default.
- W2144504927 hasBestOaLocation W21445049271 @default.
- W2144504927 hasConcept C10146269 @default.
- W2144504927 hasConcept C126322002 @default.
- W2144504927 hasConcept C134018914 @default.
- W2144504927 hasConcept C174459258 @default.
- W2144504927 hasConcept C185592680 @default.
- W2144504927 hasConcept C2778069365 @default.
- W2144504927 hasConcept C2778930706 @default.
- W2144504927 hasConcept C2779200571 @default.
- W2144504927 hasConcept C2780091579 @default.
- W2144504927 hasConcept C3675279 @default.
- W2144504927 hasConcept C55493867 @default.
- W2144504927 hasConcept C71924100 @default.
- W2144504927 hasConcept C77411442 @default.
- W2144504927 hasConceptScore W2144504927C10146269 @default.
- W2144504927 hasConceptScore W2144504927C126322002 @default.
- W2144504927 hasConceptScore W2144504927C134018914 @default.
- W2144504927 hasConceptScore W2144504927C174459258 @default.
- W2144504927 hasConceptScore W2144504927C185592680 @default.
- W2144504927 hasConceptScore W2144504927C2778069365 @default.
- W2144504927 hasConceptScore W2144504927C2778930706 @default.
- W2144504927 hasConceptScore W2144504927C2779200571 @default.
- W2144504927 hasConceptScore W2144504927C2780091579 @default.
- W2144504927 hasConceptScore W2144504927C3675279 @default.
- W2144504927 hasConceptScore W2144504927C55493867 @default.
- W2144504927 hasConceptScore W2144504927C71924100 @default.
- W2144504927 hasConceptScore W2144504927C77411442 @default.
- W2144504927 hasIssue "1" @default.
- W2144504927 hasLocation W21445049271 @default.
- W2144504927 hasLocation W21445049272 @default.
- W2144504927 hasLocation W21445049273 @default.
- W2144504927 hasLocation W21445049274 @default.
- W2144504927 hasOpenAccess W2144504927 @default.
- W2144504927 hasPrimaryLocation W21445049271 @default.
- W2144504927 hasRelatedWork W1799770855 @default.
- W2144504927 hasRelatedWork W1980957264 @default.
- W2144504927 hasRelatedWork W1984995072 @default.
- W2144504927 hasRelatedWork W2002038679 @default.
- W2144504927 hasRelatedWork W2021846613 @default.
- W2144504927 hasRelatedWork W2048449846 @default.
- W2144504927 hasRelatedWork W2071155830 @default.
- W2144504927 hasRelatedWork W2082860182 @default.
- W2144504927 hasRelatedWork W2212154849 @default.
- W2144504927 hasRelatedWork W2186282964 @default.
- W2144504927 hasVolume "13" @default.
- W2144504927 isParatext "false" @default.
- W2144504927 isRetracted "false" @default.
- W2144504927 magId "2144504927" @default.
- W2144504927 workType "article" @default.