FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144515213> ?p ?o ?g. }

• W2144515213 endingPage "41" @default.
• W2144515213 startingPage "36" @default.
• W2144515213 abstract "<h3>Abstract</h3> Stress-related illnesses such as major depressive and anxiety disorders are characterized by maladaptive physiological or behavioral responses to stressful life event. Chronic stress-based animal models have provided critical insight to a better understanding of these responses. However, currently available behavioral assays measuring chronic stress-induced phenotype in mice are limited in their design (short, not repeatable, subject to experimenter-bias) and are often inconsistent. Using the Noldus PhenoTyper apparatus, we developed a new tool to repeatedly assess behavioral changes induced by chronic stress exposure in two mouse models i.e. chronic restraint stress (CRS) and chronic unpredictable mild stress (UCMS). The PhenoTyper test consists on monitoring in home-cage setting the overnight animals’ behavior before, during and after a 1hr light challenge is applied over the food zone. After, characterization of the test, we compared the reproducibility and reliability of the PhenoTyper test in assessing the effects of chronic stress exposure, with commonly-used tests such as the elevated plus maze, open-field, novelty suppressed feeding and novelty-induced hypophagia. We found that while stress mice display heterogeneous profiles in these tests, CRS- and UCMS-exposed mice showed a very consistent response in the PhenoTyper test. Indeed, CRS and UCMS mice continue avoiding the lit zone in favor of the shelter zone. This behavior, or residual avoidance after the light challenge, lasted for hours beyond termination of the challenge, was not observed after acute stress and was consistently found throughout the chronic stress exposure in both models. Chronic stress-induced residual avoidance in the shelter was alleviated by chronic imipramine treatment but not acute diazepam administration. This new tool should be instrumental in design of longitudinal studies aiming to better understanding the trajectory of chronic stress-induced deficits in animal models and potentially screen novel anxiolytic and antidepressant treatments." @default.
• W2144515213 created "2016-06-24" @default.
• W2144515213 creator A5014641193 @default.
• W2144515213 creator A5034432112 @default.
• W2144515213 creator A5038466201 @default.
• W2144515213 creator A5050867861 @default.
• W2144515213 creator A5067719587 @default.
• W2144515213 creator A5075610512 @default.
• W2144515213 creator A5090574067 @default.
• W2144515213 date "2009-01-09" @default.
• W2144515213 modified "2023-09-27" @default.
• W2144515213 title "Polymorphisms in the IGF1 signalling pathway including the myostatin gene are associated with left ventricular mass in male athletes" @default.
• W2144515213 cites W1485259576 @default.
• W2144515213 cites W1568605582 @default.
• W2144515213 cites W1895665623 @default.
• W2144515213 cites W1963513641 @default.
• W2144515213 cites W1969066867 @default.
• W2144515213 cites W2005962156 @default.
• W2144515213 cites W2014333801 @default.
• W2144515213 cites W2018476823 @default.
• W2144515213 cites W2020620545 @default.
• W2144515213 cites W2020887103 @default.
• W2144515213 cites W2030389619 @default.
• W2144515213 cites W2033292054 @default.
• W2144515213 cites W2053079324 @default.
• W2144515213 cites W2054027756 @default.
• W2144515213 cites W2058840520 @default.
• W2144515213 cites W2060221405 @default.
• W2144515213 cites W2064664104 @default.
• W2144515213 cites W2067837318 @default.
• W2144515213 cites W2070002301 @default.
• W2144515213 cites W2072514327 @default.
• W2144515213 cites W2096073058 @default.
• W2144515213 cites W2100347223 @default.
• W2144515213 cites W2101099004 @default.
• W2144515213 cites W2104928565 @default.
• W2144515213 cites W2115927569 @default.
• W2144515213 cites W2128112859 @default.
• W2144515213 cites W2131579872 @default.
• W2144515213 cites W2140831665 @default.
• W2144515213 cites W2147047572 @default.
• W2144515213 cites W2164928197 @default.
• W2144515213 cites W2166877291 @default.
• W2144515213 cites W2172039680 @default.
• W2144515213 cites W2185382953 @default.
• W2144515213 doi "https://doi.org/10.1136/bjsm.2008.050567" @default.
• W2144515213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19136503" @default.
• W2144515213 hasPublicationYear "2009" @default.
• W2144515213 type Work @default.
• W2144515213 sameAs 2144515213 @default.
• W2144515213 citedByCount "16" @default.
• W2144515213 countsByYear W21445152132013 @default.
• W2144515213 countsByYear W21445152132014 @default.
• W2144515213 countsByYear W21445152132015 @default.
• W2144515213 countsByYear W21445152132017 @default.
• W2144515213 countsByYear W21445152132018 @default.
• W2144515213 countsByYear W21445152132019 @default.
• W2144515213 countsByYear W21445152132020 @default.
• W2144515213 countsByYear W21445152132021 @default.
• W2144515213 crossrefType "journal-article" @default.
• W2144515213 hasAuthorship W2144515213A5014641193 @default.
• W2144515213 hasAuthorship W2144515213A5034432112 @default.
• W2144515213 hasAuthorship W2144515213A5038466201 @default.
• W2144515213 hasAuthorship W2144515213A5050867861 @default.
• W2144515213 hasAuthorship W2144515213A5067719587 @default.
• W2144515213 hasAuthorship W2144515213A5075610512 @default.
• W2144515213 hasAuthorship W2144515213A5090574067 @default.
• W2144515213 hasConcept C118552586 @default.
• W2144515213 hasConcept C126322002 @default.
• W2144515213 hasConcept C15744967 @default.
• W2144515213 hasConcept C173586616 @default.
• W2144515213 hasConcept C1862650 @default.
• W2144515213 hasConcept C187288502 @default.
• W2144515213 hasConcept C2776529864 @default.
• W2144515213 hasConcept C2778654844 @default.
• W2144515213 hasConcept C2778738651 @default.
• W2144515213 hasConcept C2779085643 @default.
• W2144515213 hasConcept C2781054738 @default.
• W2144515213 hasConcept C42407357 @default.
• W2144515213 hasConcept C50610925 @default.
• W2144515213 hasConcept C548259974 @default.
• W2144515213 hasConcept C558461103 @default.
• W2144515213 hasConcept C61644593 @default.
• W2144515213 hasConcept C71924100 @default.
• W2144515213 hasConcept C77805123 @default.
• W2144515213 hasConceptScore W2144515213C118552586 @default.
• W2144515213 hasConceptScore W2144515213C126322002 @default.
• W2144515213 hasConceptScore W2144515213C15744967 @default.
• W2144515213 hasConceptScore W2144515213C173586616 @default.
• W2144515213 hasConceptScore W2144515213C1862650 @default.
• W2144515213 hasConceptScore W2144515213C187288502 @default.
• W2144515213 hasConceptScore W2144515213C2776529864 @default.
• W2144515213 hasConceptScore W2144515213C2778654844 @default.
• W2144515213 hasConceptScore W2144515213C2778738651 @default.
• W2144515213 hasConceptScore W2144515213C2779085643 @default.
• W2144515213 hasConceptScore W2144515213C2781054738 @default.
• W2144515213 hasConceptScore W2144515213C42407357 @default.
• W2144515213 hasConceptScore W2144515213C50610925 @default.

• next