Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144536721> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2144536721 endingPage "31" @default.
- W2144536721 startingPage "28" @default.
- W2144536721 abstract "Fulminant Wilson's disease (FWD) is rare and fatal condition in children unless liver transplantation is performed, however introduction of new technologies could change this poor prognosis. The aim of our study was retrospective analysis of clinical course, treatment and outcome of children with FWD treated in our institution.Between 1999-2007 we've treated in our hospital 13 patients with mean age of 15.5 yrs with FWD. We performed retrospective analysis of clinical course, biochemical parameters, MELD/PELD score, Wilson score and Kings'-College criteria for LTx in acute liver failure in all these patients. Type of treatment and final outcome were analyzed, as well as qualification for transplantation was reevaluated in each case in accordance to pathological examination of explanted during transplantation livers.The initial symptoms of FWD were typically weakness, abdominal pain and developing later after 5-60 days (mean 20 days), jaundice. Eleven patients developed neurological symptoms with coma lasting for 2-11 days before transplantation or death. Maximal serum bilirubin concentration ranged between 4.5-71.6 mg% (mean 42.24 mg%), INR 2.9-10.0 (mean 5.4). MELD/PELD score was between 21-58 (mean 38), 10 patients fulfilled general King's-College criteria for transplantation in acute liver failure. Wilson's index ranged between 11 and 17 points (mean 13 points). In 11 children urgent liver transplantation (LTx) was performed, 1 child recovered on albumin dialysis and chelating treatment, 1 child died shortly after very late referral to our center. Actual follow-up of living patients is 0.36-7.43 years (mean 2.57 yrs), all are doing well with good liver function.FWD lead to death in almost all pediatric patients if LTx can not be performed, however early introduction of albumin dialysis (MARS) and chelating therapy allowed for survival without transplantation in single patient. It seems also that MARS therapy allows for at least prolongation of waiting time for LTx. Wilson's was slightly better predictor of need for LTx in our patients than classical King's-College criteria." @default.
- W2144536721 created "2016-06-24" @default.
- W2144536721 creator A5017872044 @default.
- W2144536721 creator A5025538987 @default.
- W2144536721 creator A5027896165 @default.
- W2144536721 creator A5041241494 @default.
- W2144536721 creator A5051595274 @default.
- W2144536721 creator A5064584360 @default.
- W2144536721 creator A5074800449 @default.
- W2144536721 creator A5075399641 @default.
- W2144536721 creator A5076202692 @default.
- W2144536721 creator A5089200372 @default.
- W2144536721 date "2008-01-01" @default.
- W2144536721 modified "2023-09-26" @default.
- W2144536721 title "Liver transplantation for fulminant Wilson's disease in children." @default.
- W2144536721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18566556" @default.
- W2144536721 hasPublicationYear "2008" @default.
- W2144536721 type Work @default.
- W2144536721 sameAs 2144536721 @default.
- W2144536721 citedByCount "8" @default.
- W2144536721 countsByYear W21445367212015 @default.
- W2144536721 countsByYear W21445367212018 @default.
- W2144536721 countsByYear W21445367212021 @default.
- W2144536721 crossrefType "journal-article" @default.
- W2144536721 hasAuthorship W2144536721A5017872044 @default.
- W2144536721 hasAuthorship W2144536721A5025538987 @default.
- W2144536721 hasAuthorship W2144536721A5027896165 @default.
- W2144536721 hasAuthorship W2144536721A5041241494 @default.
- W2144536721 hasAuthorship W2144536721A5051595274 @default.
- W2144536721 hasAuthorship W2144536721A5064584360 @default.
- W2144536721 hasAuthorship W2144536721A5074800449 @default.
- W2144536721 hasAuthorship W2144536721A5075399641 @default.
- W2144536721 hasAuthorship W2144536721A5076202692 @default.
- W2144536721 hasAuthorship W2144536721A5089200372 @default.
- W2144536721 hasConcept C100136789 @default.
- W2144536721 hasConcept C120665830 @default.
- W2144536721 hasConcept C121332964 @default.
- W2144536721 hasConcept C126322002 @default.
- W2144536721 hasConcept C141071460 @default.
- W2144536721 hasConcept C167135981 @default.
- W2144536721 hasConcept C187212893 @default.
- W2144536721 hasConcept C2777075537 @default.
- W2144536721 hasConcept C2778456037 @default.
- W2144536721 hasConcept C2779609443 @default.
- W2144536721 hasConcept C2779978075 @default.
- W2144536721 hasConcept C2911091166 @default.
- W2144536721 hasConcept C2911118192 @default.
- W2144536721 hasConcept C71924100 @default.
- W2144536721 hasConcept C90924648 @default.
- W2144536721 hasConceptScore W2144536721C100136789 @default.
- W2144536721 hasConceptScore W2144536721C120665830 @default.
- W2144536721 hasConceptScore W2144536721C121332964 @default.
- W2144536721 hasConceptScore W2144536721C126322002 @default.
- W2144536721 hasConceptScore W2144536721C141071460 @default.
- W2144536721 hasConceptScore W2144536721C167135981 @default.
- W2144536721 hasConceptScore W2144536721C187212893 @default.
- W2144536721 hasConceptScore W2144536721C2777075537 @default.
- W2144536721 hasConceptScore W2144536721C2778456037 @default.
- W2144536721 hasConceptScore W2144536721C2779609443 @default.
- W2144536721 hasConceptScore W2144536721C2779978075 @default.
- W2144536721 hasConceptScore W2144536721C2911091166 @default.
- W2144536721 hasConceptScore W2144536721C2911118192 @default.
- W2144536721 hasConceptScore W2144536721C71924100 @default.
- W2144536721 hasConceptScore W2144536721C90924648 @default.
- W2144536721 hasIssue "2" @default.
- W2144536721 hasLocation W21445367211 @default.
- W2144536721 hasOpenAccess W2144536721 @default.
- W2144536721 hasPrimaryLocation W21445367211 @default.
- W2144536721 hasRelatedWork W1700376154 @default.
- W2144536721 hasRelatedWork W1843774658 @default.
- W2144536721 hasRelatedWork W1966896568 @default.
- W2144536721 hasRelatedWork W1975054110 @default.
- W2144536721 hasRelatedWork W1996192652 @default.
- W2144536721 hasRelatedWork W2016494445 @default.
- W2144536721 hasRelatedWork W2017821181 @default.
- W2144536721 hasRelatedWork W2045623736 @default.
- W2144536721 hasRelatedWork W2062331704 @default.
- W2144536721 hasRelatedWork W2079522949 @default.
- W2144536721 hasRelatedWork W2089658195 @default.
- W2144536721 hasRelatedWork W2093554033 @default.
- W2144536721 hasRelatedWork W2114343250 @default.
- W2144536721 hasRelatedWork W2141060691 @default.
- W2144536721 hasRelatedWork W2147578628 @default.
- W2144536721 hasRelatedWork W2360894560 @default.
- W2144536721 hasRelatedWork W2560531552 @default.
- W2144536721 hasRelatedWork W2568504473 @default.
- W2144536721 hasRelatedWork W273166496 @default.
- W2144536721 hasRelatedWork W3199799577 @default.
- W2144536721 hasVolume "13" @default.
- W2144536721 isParatext "false" @default.
- W2144536721 isRetracted "false" @default.
- W2144536721 magId "2144536721" @default.
- W2144536721 workType "article" @default.