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- W2144548580 abstract "Piperidine derivatives are reported to exhibit a variety of pharmacological activities. In this article, synthesis and aspartic protease inhibitory activity of three nitrophenacyl derivatives of N-methyl-4-hydroxy piperidine are reported. Enzyme assays showed that the attachment of a nitro group in the benzene ring plays an important role in the inhibition of plasmepsin-II of Plasmodium falciparum. The compound 1-methyl-1-(4’-nitrophenacyl)-4-hydroxypiperidinium bromide (3), consisting of a nitro group at the para position, was the most active at the concentration of 1.0 µM. The activity of the compounds was evaluated through the observed orientation and diagrammatic representation of nitrophenacyl derivatives of 4-hydroxy piperidine." @default.
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- W2144548580 date "2011-12-01" @default.
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- W2144548580 title "Characterisation ofPlasmodium falciparumaspartic protease inhibition by piperidine derivatives" @default.
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- W2144548580 doi "https://doi.org/10.1080/14786419.2010.541881" @default.
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