FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144550666> ?p ?o ?g. }

• W2144550666 endingPage "68" @default.
• W2144550666 startingPage "60" @default.
• W2144550666 abstract "Pr60gag appears to be the only protein encoded by the murine AIDS (MAIDS)-defective virus. To study the role of Pr60gag or some other sequences of the viral genome in the pathogenicity of the virus, we have generated mutants of the defective viral genome. These mutant defective viruses, prepared as helper-free stocks, were inoculated into susceptible C57BL/6 mice. Mutant Du5H-A virus, which had a stop codon within gag MA(p15), did not induce target cell proliferation or MAIDS. Mutants Du5H-B and -C encoded truncated Pr60gag proteins containing, respectively, MA(p15)-p12 or MA(p15)-p12 and part of CA(p30). These mutants showed a very limited capacity to induce early cell expansion and were poorly pathogenic. Only recombinant (revertant) viruses were recovered from organs of diseased mice inoculated with these two mutants. Mutant Du5H-D was generated by deleting 1.4 kbp of the 3'-end sequences, outside the gag coding region. The levels of RNA and proteins made by this mutant were low. This mutant also reverting frequently but was nevertheless able to induce MAIDS at a low efficiency without reverting. Our results indicate that the Pr60gag protein is necessary and sufficient to induce MAIDS. These data also suggest that the Pr60gag protein needs to be relatively intact to be fully pathogenic. In addition, our study shows a very high reversion rate of some mutants and emphasizes the need to check for the presence of revertant (recombinant) viruses in diseased organs when working with mutants of the MAIDS-defective virus." @default.
• W2144550666 created "2016-06-24" @default.
• W2144550666 creator A5026594337 @default.
• W2144550666 creator A5041700739 @default.
• W2144550666 creator A5082333058 @default.
• W2144550666 date "1995-01-01" @default.
• W2144550666 modified "2023-10-14" @default.
• W2144550666 title "Mutational analysis of the murine AIDS-defective viral genome reveals a high reversion rate in vivo and a requirement for an intact Pr60gag protein for efficient induction of disease" @default.
• W2144550666 cites W1498992791 @default.
• W2144550666 cites W1545320217 @default.
• W2144550666 cites W1559326716 @default.
• W2144550666 cites W1563013015 @default.
• W2144550666 cites W1563048857 @default.
• W2144550666 cites W1580893794 @default.
• W2144550666 cites W1607224345 @default.
• W2144550666 cites W1897890183 @default.
• W2144550666 cites W1918118064 @default.
• W2144550666 cites W1928939008 @default.
• W2144550666 cites W1985077359 @default.
• W2144550666 cites W1987870163 @default.
• W2144550666 cites W2011537940 @default.
• W2144550666 cites W2014963034 @default.
• W2144550666 cites W2023236405 @default.
• W2144550666 cites W2023763412 @default.
• W2144550666 cites W2033613795 @default.
• W2144550666 cites W2059289017 @default.
• W2144550666 cites W2059633680 @default.
• W2144550666 cites W2094657382 @default.
• W2144550666 cites W2097416522 @default.
• W2144550666 cites W2125425768 @default.
• W2144550666 cites W2134812217 @default.
• W2144550666 cites W2151290359 @default.
• W2144550666 cites W2403846735 @default.
• W2144550666 cites W4294216491 @default.
• W2144550666 cites W2046713080 @default.
• W2144550666 doi "https://doi.org/10.1128/jvi.69.1.60-68.1995" @default.
• W2144550666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/188548" @default.
• W2144550666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7983763" @default.
• W2144550666 hasPublicationYear "1995" @default.
• W2144550666 type Work @default.
• W2144550666 sameAs 2144550666 @default.
• W2144550666 citedByCount "11" @default.
• W2144550666 crossrefType "journal-article" @default.
• W2144550666 hasAuthorship W2144550666A5026594337 @default.
• W2144550666 hasAuthorship W2144550666A5041700739 @default.
• W2144550666 hasAuthorship W2144550666A5082333058 @default.
• W2144550666 hasBestOaLocation W21445506661 @default.
• W2144550666 hasConcept C104317684 @default.
• W2144550666 hasConcept C127716648 @default.
• W2144550666 hasConcept C141231307 @default.
• W2144550666 hasConcept C143065580 @default.
• W2144550666 hasConcept C153911025 @default.
• W2144550666 hasConcept C159047783 @default.
• W2144550666 hasConcept C2522874641 @default.
• W2144550666 hasConcept C2779926675 @default.
• W2144550666 hasConcept C40767141 @default.
• W2144550666 hasConcept C501734568 @default.
• W2144550666 hasConcept C54355233 @default.
• W2144550666 hasConcept C67705224 @default.
• W2144550666 hasConcept C6881719 @default.
• W2144550666 hasConcept C70883133 @default.
• W2144550666 hasConcept C86803240 @default.
• W2144550666 hasConceptScore W2144550666C104317684 @default.
• W2144550666 hasConceptScore W2144550666C127716648 @default.
• W2144550666 hasConceptScore W2144550666C141231307 @default.
• W2144550666 hasConceptScore W2144550666C143065580 @default.
• W2144550666 hasConceptScore W2144550666C153911025 @default.
• W2144550666 hasConceptScore W2144550666C159047783 @default.
• W2144550666 hasConceptScore W2144550666C2522874641 @default.
• W2144550666 hasConceptScore W2144550666C2779926675 @default.
• W2144550666 hasConceptScore W2144550666C40767141 @default.
• W2144550666 hasConceptScore W2144550666C501734568 @default.
• W2144550666 hasConceptScore W2144550666C54355233 @default.
• W2144550666 hasConceptScore W2144550666C67705224 @default.
• W2144550666 hasConceptScore W2144550666C6881719 @default.
• W2144550666 hasConceptScore W2144550666C70883133 @default.
• W2144550666 hasConceptScore W2144550666C86803240 @default.
• W2144550666 hasIssue "1" @default.
• W2144550666 hasLocation W21445506661 @default.
• W2144550666 hasLocation W21445506662 @default.
• W2144550666 hasLocation W21445506663 @default.
• W2144550666 hasOpenAccess W2144550666 @default.
• W2144550666 hasPrimaryLocation W21445506661 @default.
• W2144550666 hasRelatedWork W101124211 @default.
• W2144550666 hasRelatedWork W1978096759 @default.
• W2144550666 hasRelatedWork W1987599063 @default.
• W2144550666 hasRelatedWork W2009647017 @default.
• W2144550666 hasRelatedWork W2060397969 @default.
• W2144550666 hasRelatedWork W2125711067 @default.
• W2144550666 hasRelatedWork W2129098602 @default.
• W2144550666 hasRelatedWork W2357939498 @default.
• W2144550666 hasRelatedWork W2469690717 @default.
• W2144550666 hasRelatedWork W81991004 @default.
• W2144550666 hasVolume "69" @default.
• W2144550666 isParatext "false" @default.
• W2144550666 isRetracted "false" @default.
• W2144550666 magId "2144550666" @default.
• W2144550666 workType "article" @default.