FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144602786> ?p ?o ?g. }

• W2144602786 endingPage "296" @default.
• W2144602786 startingPage "286" @default.
• W2144602786 abstract "Cannabidiol is a non-psychotomimetic constituent of Cannabis sativa, which induces central effects in rodents. It has been shown that cannabidiol attenuates cue-induced reinstatement of heroin seeking. However, to the best of our knowledge, its effects on brain stimulation reward and the reward-facilitating effects of drugs of abuse have not yet been examined. Therefore, we investigated the effects of cannabidiol on brain reward function and on the reward-facilitating effect of morphine and cocaine using the intracranial self-stimulation (ICSS) paradigm. Rats were prepared with a stimulating electrode into the medial forebrain bundle (MFB), and a guide cannula into the dorsal raphe (microinjection experiments), and were trained to respond for electrical brain stimulation. A low dose of cannabidiol did not affect the reinforcing efficacy of brain stimulation, whereas higher doses significantly elevated the threshold frequency required for MFB ICSS. Both cocaine and morphine lowered ICSS thresholds. Cannabidiol inhibited the reward-facilitating effect of morphine, but not cocaine. This effect was reversed by pre-treatment with an intra-dorsal raphe injection of the selective 5-HT1A receptor antagonist WAY-100635. The present findings indicate that cannabidiol does not exhibit reinforcing properties in the ICSS paradigm at any of the doses tested, while it decreases the reward-facilitating effects of morphine. These effects were mediated by activation of 5-HT1A receptors in the dorsal raphe. Our results suggest that cannabidiol interferes with brain reward mechanisms responsible for the expression of the acute reinforcing properties of opioids, thus indicating that cannabidiol may be clinically useful in attenuating the rewarding effects of opioids." @default.
• W2144602786 created "2016-06-24" @default.
• W2144602786 creator A5017720553 @default.
• W2144602786 creator A5026542280 @default.
• W2144602786 creator A5052349126 @default.
• W2144602786 date "2012-08-02" @default.
• W2144602786 modified "2023-09-26" @default.
• W2144602786 title "Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT_1Areceptors in the dorsal raphe nucleus" @default.
• W2144602786 cites W1497893548 @default.
• W2144602786 cites W1964715350 @default.
• W2144602786 cites W1972435539 @default.
• W2144602786 cites W1979642301 @default.
• W2144602786 cites W1985380299 @default.
• W2144602786 cites W1985737113 @default.
• W2144602786 cites W1987380121 @default.
• W2144602786 cites W1988343602 @default.
• W2144602786 cites W1988659186 @default.
• W2144602786 cites W1989353122 @default.
• W2144602786 cites W1992318166 @default.
• W2144602786 cites W1994742271 @default.
• W2144602786 cites W2003758042 @default.
• W2144602786 cites W2005752860 @default.
• W2144602786 cites W2009270015 @default.
• W2144602786 cites W2015441565 @default.
• W2144602786 cites W2015725514 @default.
• W2144602786 cites W2016169730 @default.
• W2144602786 cites W2020825180 @default.
• W2144602786 cites W2030623240 @default.
• W2144602786 cites W2032403875 @default.
• W2144602786 cites W2033440445 @default.
• W2144602786 cites W2038374406 @default.
• W2144602786 cites W2041273498 @default.
• W2144602786 cites W2047282591 @default.
• W2144602786 cites W2048744334 @default.
• W2144602786 cites W2052034283 @default.
• W2144602786 cites W2052532655 @default.
• W2144602786 cites W2058051322 @default.
• W2144602786 cites W2062796486 @default.
• W2144602786 cites W2065788111 @default.
• W2144602786 cites W2081969306 @default.
• W2144602786 cites W2081986155 @default.
• W2144602786 cites W2083994361 @default.
• W2144602786 cites W2085594551 @default.
• W2144602786 cites W2087748457 @default.
• W2144602786 cites W2091054811 @default.
• W2144602786 cites W2091997345 @default.
• W2144602786 cites W2093116126 @default.
• W2144602786 cites W2101233587 @default.
• W2144602786 cites W2103386780 @default.
• W2144602786 cites W2105611457 @default.
• W2144602786 cites W2106232499 @default.
• W2144602786 cites W2107678707 @default.
• W2144602786 cites W2109595530 @default.
• W2144602786 cites W2109918996 @default.
• W2144602786 cites W2115573652 @default.
• W2144602786 cites W2117932036 @default.
• W2144602786 cites W2122324389 @default.
• W2144602786 cites W2149110258 @default.
• W2144602786 cites W2151544333 @default.
• W2144602786 cites W2157971597 @default.
• W2144602786 cites W2158987544 @default.
• W2144602786 cites W2168111104 @default.
• W2144602786 cites W2170388379 @default.
• W2144602786 cites W2174764226 @default.
• W2144602786 cites W2485023302 @default.
• W2144602786 cites W4242500439 @default.
• W2144602786 doi "https://doi.org/10.1111/j.1369-1600.2012.00483.x" @default.
• W2144602786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22862835" @default.
• W2144602786 hasPublicationYear "2012" @default.
• W2144602786 type Work @default.
• W2144602786 sameAs 2144602786 @default.
• W2144602786 citedByCount "104" @default.
• W2144602786 countsByYear W21446027862013 @default.
• W2144602786 countsByYear W21446027862014 @default.
• W2144602786 countsByYear W21446027862015 @default.
• W2144602786 countsByYear W21446027862016 @default.
• W2144602786 countsByYear W21446027862017 @default.
• W2144602786 countsByYear W21446027862018 @default.
• W2144602786 countsByYear W21446027862019 @default.
• W2144602786 countsByYear W21446027862020 @default.
• W2144602786 countsByYear W21446027862021 @default.
• W2144602786 countsByYear W21446027862022 @default.
• W2144602786 countsByYear W21446027862023 @default.
• W2144602786 crossrefType "journal-article" @default.
• W2144602786 hasAuthorship W2144602786A5017720553 @default.
• W2144602786 hasAuthorship W2144602786A5026542280 @default.
• W2144602786 hasAuthorship W2144602786A5052349126 @default.
• W2144602786 hasConcept C118552586 @default.
• W2144602786 hasConcept C126322002 @default.
• W2144602786 hasConcept C137183658 @default.
• W2144602786 hasConcept C15744967 @default.
• W2144602786 hasConcept C169760540 @default.
• W2144602786 hasConcept C170493617 @default.
• W2144602786 hasConcept C24998067 @default.
• W2144602786 hasConcept C2775864247 @default.
• W2144602786 hasConcept C2776552330 @default.
• W2144602786 hasConcept C2776669363 @default.
• W2144602786 hasConcept C2776895053 @default.

• next