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- W2144609004 abstract "V(D)J recombination is thought to be regulated by changes in the accessibility of target sites, such as modulation of methylation. To test whether demethylation of the kappa locus can activate recombination, we generated two recombinationally active B cell lines in which the gene for maintenance of genomic DNA methylation, Dnmt1, was flanked with loxP sites. Transduction with a retrovirus expressing both the cre recombinase and green fluorescent protein allowed us to purify recombinationally active cells devoid of methylation. Loss of methylation of the kappa locus was not sufficient to activate recombination, although transcription was activated in one line. It appears that demethylation of the kappa locus is not the rate-limiting step for altering accessibility and thus regulated demethylation does not generate specificity of recombination." @default.
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- W2144609004 date "2000-07-04" @default.
- W2144609004 modified "2023-09-26" @default.
- W2144609004 title "V(D)J recombination is not activated by demethylation of the kappa locus" @default.
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- W2144609004 doi "https://doi.org/10.1073/pnas.150218497" @default.
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