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• W2144630411 endingPage "170" @default.
• W2144630411 startingPage "155" @default.
• W2144630411 abstract "We have isolated and characterised two divergent simian T-lymphotropic viruses (STLV), not belonging to the established human and simian T-lymphotropic virus lineages HTLV-1/STLV-1 and HTLV-2. STLV-L, from an Eritrean sacred baboon (Papio hamadryas), has been typed as a third type of simian T-lymphotropic virus, distinct from HTLV-1/STLV-1 and HTLV-2. The other virus, isolated from Congolese bonobos (Pan paniscus), is a distinct member of the HTLV-2 clade and has been designated STLV-2. The isolation of these two simian viruses shows that the spectrum of HTLVs/STLVs is larger than previously expected. Our data indicate that the two lineages STLV-L and HTLV-2/STLV-2 are of African origin, while the HTLV-1/STLV-1 lineage has been shown to be of Asian origin. These data, together with our phylogenetic analyses, suggest an African origin of the HTLV/STLV ancestor, which provides new clues about virus dissemination. Furthermore, the atypical serological profiles exhibited by STLV-L or STLV-2 infected animals in western blot, raise questions about the efficiency of current screening methods to type highly divergent HTLVs/STLVs. Considering the growing interest in xenotransplantations, more epidemiological and biological knowledge of simian and human T-lymphotropic viruses is necessary to estimate the risk of interspecies transmissions." @default.
• W2144630411 created "2016-06-24" @default.
• W2144630411 creator A5005816130 @default.
• W2144630411 creator A5019719611 @default.
• W2144630411 creator A5030387965 @default.
• W2144630411 creator A5065034994 @default.
• W2144630411 creator A5075613942 @default.
• W2144630411 creator A5088355541 @default.
• W2144630411 date "1999-07-01" @default.
• W2144630411 modified "2023-10-16" @default.
• W2144630411 title "The discovery of two new divergent STLVs has implications for the evolution and epidemiology of HTLVs" @default.
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