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- W2144631899 abstract "Studies have suggested a relationship between inflammation and thrombosis in several clinical conditions. However, there are limited data on the possible association between inflammation and markers of thromboembolic risk on transoesophageal echocardiography (TEE) in patients with atrial fibrillation (AF). Thus, we assessed C-reactive protein levels in a total of 70 consecutive patients with non-valvular AF lasting ¾48 hours undergoing TEE. Patients were divided into two groups according to presence (n=22) or absence (n=48) of dense spontaneous echo contrast (SES) in left atrium or left atrial appendage, assessed by TEE. Dense SEC was not related to age, sex, main risk factors, fibrinogen or D-dimer levels, however patients with dense SEC had lower peak left atrial appendage velocity at TEE (0.38±0.21 vs 0.55±0.21 m/sec, P=0.009). High CRP levels (¾3 mg/L) were also significantly associated with dense SEC. Multivariate analysis showed that only peak left atrial appendage velocity and CRP were significantly associated with dense SEC, with an odds ratio of 4.1 (95% confidence interval 1.3–13) for CRP and 3.9 (95% confidence interval 1.3-12) for peak leaft atrial appendage velocity. Interestingly, CRP levels were not related to peak velocity, suggesting that these two markers may identify two different components of thromboembolic risk (inflammation and stasis) In conclusion, our result suggest that both inflammation and stasis play a role in the pathogenesis of thromboembolism in atrial fibrillation." @default.
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- W2144631899 date "2005-05-01" @default.
- W2144631899 modified "2023-10-18" @default.
- W2144631899 title "Inflammation and markers of thromboembolic risk on transoesophageal echocardiography in atrial fibrillation" @default.
- W2144631899 doi "https://doi.org/10.1016/j.hrthm.2005.02.841" @default.
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