Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144644911> ?p ?o ?g. }
- W2144644911 endingPage "204" @default.
- W2144644911 startingPage "191" @default.
- W2144644911 abstract "Abstract Significant progress has been made in the development of several nonpeptide antagonists of the type 1 receptor for corticotropin‐releasing factor (CRF). The present review outlines the properties of this drug class that point to their potential as agents for depression and/or anxiety. Behavioral tests of CRF 1 receptor antagonists relevant to depression have been mixed. For example, most CRF 1 receptor antagonists did not lower swim test immobility in a subacute paradigm, where three injections of the drug are given in the 24 hrs between a 15‐min pre‐swim and a 5‐min test swim. However, reliable effects in other tests of antidepressant action were observed in the chronic mild stress protocol or the Flinders Sensitive Line rat that exhibits innately high swim test immobility when the drugs were given chronically. Because these latter tests have a very good record of predicting antidepressant activity, CRF 1 receptor antagonists are good candidates for clinical trials for depression. Evidence indicates that the CRF 1 receptor antagonists do not exhibit changes in anxiety‐like behavior under basal conditions. However, this drug class effectively blocks the anxiogenic states produced by withdrawal from chronic alcohol, by exposure to stress, or in rats selectively bred for high anxiety. CRF 1 receptor antagonists also prevent the anxiety associated with multiple ethanol withdrawals when given only during the earlier withdrawals. Thus, these agents may also have clinically relevant anxiolytic effects, not only in individuals with anxiety disorders but also in individuals who have anxiety episodes during alcohol or drug withdrawal. Drug Dev. Res. 65:191–204, 2005. © 2005 Wiley‐Liss, Inc." @default.
- W2144644911 created "2016-06-24" @default.
- W2144644911 creator A5026416051 @default.
- W2144644911 creator A5060859899 @default.
- W2144644911 creator A5067192678 @default.
- W2144644911 date "2005-08-01" @default.
- W2144644911 modified "2023-09-25" @default.
- W2144644911 title "Can CRF1 receptor antagonists become antidepressant and/or anxiolytic agents?" @default.
- W2144644911 cites W114026363 @default.
- W2144644911 cites W1518512325 @default.
- W2144644911 cites W1527225576 @default.
- W2144644911 cites W1572525448 @default.
- W2144644911 cites W1575948347 @default.
- W2144644911 cites W1921355205 @default.
- W2144644911 cites W1964516381 @default.
- W2144644911 cites W1964838523 @default.
- W2144644911 cites W1967709356 @default.
- W2144644911 cites W1968638036 @default.
- W2144644911 cites W1969702154 @default.
- W2144644911 cites W1970920529 @default.
- W2144644911 cites W1973994559 @default.
- W2144644911 cites W1975218744 @default.
- W2144644911 cites W1977430165 @default.
- W2144644911 cites W1977567826 @default.
- W2144644911 cites W1979024772 @default.
- W2144644911 cites W1979420282 @default.
- W2144644911 cites W1980012680 @default.
- W2144644911 cites W1982335931 @default.
- W2144644911 cites W1982843079 @default.
- W2144644911 cites W1986673468 @default.
- W2144644911 cites W1988230174 @default.
- W2144644911 cites W1991262327 @default.
- W2144644911 cites W1994328423 @default.
- W2144644911 cites W1996917770 @default.
- W2144644911 cites W1997841428 @default.
- W2144644911 cites W1998298073 @default.
- W2144644911 cites W2000031660 @default.
- W2144644911 cites W2000878731 @default.
- W2144644911 cites W2003973769 @default.
- W2144644911 cites W2006218562 @default.
- W2144644911 cites W2006449302 @default.
- W2144644911 cites W2007977295 @default.
- W2144644911 cites W2008197220 @default.
- W2144644911 cites W2009058487 @default.
- W2144644911 cites W2014973328 @default.
- W2144644911 cites W2016432743 @default.
- W2144644911 cites W2016605777 @default.
- W2144644911 cites W2017124573 @default.
- W2144644911 cites W2022290338 @default.
- W2144644911 cites W2022987442 @default.
- W2144644911 cites W2023414423 @default.
- W2144644911 cites W2025294582 @default.
- W2144644911 cites W2026026067 @default.
- W2144644911 cites W2027062631 @default.
- W2144644911 cites W2037111632 @default.
- W2144644911 cites W2038035845 @default.
- W2144644911 cites W2040103405 @default.
- W2144644911 cites W2041561931 @default.
- W2144644911 cites W2043524974 @default.
- W2144644911 cites W2044069216 @default.
- W2144644911 cites W2044738582 @default.
- W2144644911 cites W2045417336 @default.
- W2144644911 cites W2046725716 @default.
- W2144644911 cites W2046934118 @default.
- W2144644911 cites W2047810860 @default.
- W2144644911 cites W2048417345 @default.
- W2144644911 cites W2048988744 @default.
- W2144644911 cites W2050021971 @default.
- W2144644911 cites W2055647516 @default.
- W2144644911 cites W2057200138 @default.
- W2144644911 cites W2060050690 @default.
- W2144644911 cites W2061936774 @default.
- W2144644911 cites W2061983836 @default.
- W2144644911 cites W2063360806 @default.
- W2144644911 cites W2064332293 @default.
- W2144644911 cites W2065139995 @default.
- W2144644911 cites W2066457796 @default.
- W2144644911 cites W2067761581 @default.
- W2144644911 cites W2071736830 @default.
- W2144644911 cites W2075437463 @default.
- W2144644911 cites W2079714688 @default.
- W2144644911 cites W2079718339 @default.
- W2144644911 cites W2080475141 @default.
- W2144644911 cites W2082146795 @default.
- W2144644911 cites W2083056265 @default.
- W2144644911 cites W2085272519 @default.
- W2144644911 cites W2087334617 @default.
- W2144644911 cites W2089299823 @default.
- W2144644911 cites W2091064555 @default.
- W2144644911 cites W2091831858 @default.
- W2144644911 cites W2093267260 @default.
- W2144644911 cites W2098391261 @default.
- W2144644911 cites W2114524512 @default.
- W2144644911 cites W2116777802 @default.
- W2144644911 cites W2120947452 @default.
- W2144644911 cites W2123536534 @default.
- W2144644911 cites W2123923673 @default.
- W2144644911 cites W2125837141 @default.