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• W2144647523 abstract "Abstract— Photochemical and photobiological properties of a new isoster of psoralen, 4, 4′, 5′-trimethyl-8-azapsoralen (4, 4′, 5′-TMAP), have been studied. This compound shows a high DNA-photobinding rate, higher than that of 8-methoxypsoralen (8-MOP), forming both monoadducts and inter-strand cross-links. The yield of cross-links, however, is markedly lower than that of 8-MOP. Antiproliferative activity of 4, 4′, 5′-TMAP, in terms of DNA synthesis inhibition in Ehrlich ascites tumor cells, is higher than that of 8-MOP. Mutagenic activity on E. coli WP2 R46+ cells appeared similar to or even lower than that of 8-MOP. This new compound applied on depilated guinea pig skin and irradiated with UVA did not show any skin-phototoxicity. On the basis of these properties 4, 4′, 5′-TMAP appears to be a potential photochemotherapeutic agent." @default.
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• W2144647523 date "1991-01-01" @default.
• W2144647523 modified "2023-09-30" @default.
• W2144647523 title "4, 4', 5'-TRIMETHYL-8-AZAPSORALEN, A NEW-PHOTOREACTIVE AND NON-SKIN-PHOTOTOXIC BIFUNCTIONAL BIOISOSTER OF PSORALEN" @default.
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• W2144647523 doi "https://doi.org/10.1111/j.1751-1097.1991.tb08480.x" @default.
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