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- W2144652537 abstract "The sequence-specific formation of R-loops can be assayed using RNAs which overlap a Hin dIII cleavage site in a 3.5 kb plasmid. Chemical modification of the displaced DNA strand has permitted stabilization of these R-loops and allowed a systematic investigation of the dependence of these triple-stranded structures on the chain length and structure of the input RNA. RNAs as short as 50 nt form stable R-loops if 5-allylamine uridines (U aa -RNA) are used in place of normal uridines; normal RNAs must be 100 nt long to form R-loops quantitatively. Since acetic anhydride decreases the hybridization efficiency of U aa -RNAs, the positive charge of the RNAs must diminish the electrostatic repulsion of the three negatively charged phosphodiester backbones. The dependence of R-loop stability on the length of RNA can be simulated with a random walk model, which also applies to strand migration within Holiday junctions. R-loop hybridization provides a versatile method to generate single-stranded DNA in a sequence-selective manner." @default.
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- W2144652537 date "1995-01-01" @default.
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- W2144652537 title "R-loop stability as a function of RNA structure and size" @default.
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- W2144652537 doi "https://doi.org/10.1093/nar/23.17.3516" @default.
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