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- W2144653505 abstract "The excretion and metabolic fate of two cephalosporin antibiotics, cephachlomezine (CEC), and its parent compound, m-chlorophenyl-acetamidocephalosporanic acid (m-Cl-PACA), was studied in rats, with emphasis being placed on biliary excretion and serum protein binding. When 14C-m-Cl-PACAwas given intramuscularly, about 40 percent of the administered radioactivity was found in the bile, which contained only 1.6 %of the administered antibiotic activity. Lactone of m-Cl-PACA, one of the metabolites of m-Cl-PACA, has beei isolated in a crystalline form as a result of hydrolysis by citrus acetylase. After a single intramuscular administration of 14C-CEC, more than 60 % of the administered dose was excreted in urine in the unchanged form and 15 % was recovered either in the bile as shown by radioassay or in microbioassay. Orally administered 14C-CEC underwent suspected degradation in the gut. Binding of CECand m-Cl-PACAto serum protein was examined by means of an ultra filtration technique chiefly in relation to the biliary excretion." @default.
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- W2144653505 date "1971-01-01" @default.
- W2144653505 modified "2023-09-28" @default.
- W2144653505 title "STUDIES ON THE METABOLISM OF CEPHALOSPORINS. II" @default.
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- W2144653505 doi "https://doi.org/10.7164/antibiotics.24.667" @default.
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