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• W2144656189 abstract "ABSTRACT In a survey of class 1 integrons from human stools, an unusual class 1 integron from a strain of Enterobacter cloacae was isolated and characterized in detail. Sequence analysis of a fosmid containing the class 1 integron revealed a complex set of transposons which included two Tn 402 -like transposons. One of these transposons, Tn 6007 , included a class 1 integron with two non-antibiotic-resistance-type gene cassettes and a complete transposition module. This tni module is a hybrid with a boundary within the res site compared to Tn 402 , implying that a site-specific recombination event generated either Tn 6007 or Tn 402 . The second Tn 402 -like transposon, Tn 6008 , possesses neither a mer operon nor an integron, and most of its tni module has been deleted. Tn 6007 , Tn 6008 , and the 2,478 bases between them, collectively designated Tn 6006 , have transposed into a Tn 5036 /Tn 3926 -like transposon as a single unit. Tn 6006 , Tn 6007 , and Tn 6008 could all transpose as discrete entities. Database analysis also revealed that a version of Tn 6008 was present in the genome of Xanthomonas campestris pv. vesicatoria. Overall, the E. cloacae isolate further demonstrated that functional class 1 integrons/transposons are probably common in bacterial communities and have the potential to add substantially to the problem of multidrug-resistant nosocomial infections." @default.
• W2144656189 created "2016-06-24" @default.
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• W2144656189 date "2008-08-01" @default.
• W2144656189 modified "2023-10-17" @default.
• W2144656189 title "A Class 1 Integron Present in a Human Commensal Has a Hybrid Transposition Module Compared to Tn <i>402</i> : Evidence of Interaction with Mobile DNA from Natural Environments" @default.
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• W2144656189 doi "https://doi.org/10.1128/jb.00199-08" @default.
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