FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144664904> ?p ?o ?g. }

• W2144664904 endingPage "968" @default.
• W2144664904 startingPage "960" @default.
• W2144664904 abstract "Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR)-δ has been shown to improve insulin resistance, adiposity, and plasma HDL levels. Several studies have reported that activation of PPARδ is atheroprotective; however, the role of PPARδ in renal function remains unclear. Here, we report the renoprotective effects of PPARδ activation in a model of streptozotocin-induced diabetic nephropathy.Eight-week-old male C57BL/6 mice were divided into three groups: 1) nondiabetic control mice, 2) diabetic mice, and 3) diabetic mice treated with the PPARδ agonist GW0742 (1 mg/kg/day). GW0742 was administered by gavage for 8 weeks after inducing diabetes.GW0742 decreased urinary albumin excretion without altering blood glucose levels. Macrophage infiltration, mesangial matrix accumulation, and type IV collagen deposition were substantially attenuated by GW0742. The gene expression of inflammatory mediators in the kidney cortex, such as monocyte chemoattractant protein-1 (MCP-1) and osteopontin (OPN), was also suppressed. In vitro studies demonstrated that PPARδ activation increased the expression of anti-inflammatory corepressor B-cell lymphoma-6, which subsequently suppressed MCP-1 and OPN expression.These findings uncover a previously unrecognized mechanism for the renoprotective effects of PPARδ agonists and support the concept that PPARδ agonists may offer a novel therapeutic approach for the treatment of diabetic nephropathy." @default.
• W2144664904 created "2016-06-24" @default.
• W2144664904 creator A5003430784 @default.
• W2144664904 creator A5007276836 @default.
• W2144664904 creator A5010378457 @default.
• W2144664904 creator A5032191719 @default.
• W2144664904 creator A5033338291 @default.
• W2144664904 creator A5039655833 @default.
• W2144664904 creator A5040159416 @default.
• W2144664904 creator A5080291594 @default.
• W2144664904 creator A5089180594 @default.
• W2144664904 date "2011-02-21" @default.
• W2144664904 modified "2023-09-25" @default.
• W2144664904 title "Activation of Peroxisome Proliferator–Activated Receptor δ Inhibits Streptozotocin-Induced Diabetic Nephropathy Through Anti-Inflammatory Mechanisms in Mice" @default.
• W2144664904 cites W1970952359 @default.
• W2144664904 cites W1973436528 @default.
• W2144664904 cites W1985516506 @default.
• W2144664904 cites W1998378885 @default.
• W2144664904 cites W2001512276 @default.
• W2144664904 cites W2014259643 @default.
• W2144664904 cites W2017671227 @default.
• W2144664904 cites W2019792823 @default.
• W2144664904 cites W2025211073 @default.
• W2144664904 cites W2042646534 @default.
• W2144664904 cites W2043828707 @default.
• W2144664904 cites W2045926020 @default.
• W2144664904 cites W2046021057 @default.
• W2144664904 cites W2049177531 @default.
• W2144664904 cites W2053389410 @default.
• W2144664904 cites W2079785479 @default.
• W2144664904 cites W2081272963 @default.
• W2144664904 cites W2083911580 @default.
• W2144664904 cites W2087511197 @default.
• W2144664904 cites W2102634499 @default.
• W2144664904 cites W2105662115 @default.
• W2144664904 cites W2116197163 @default.
• W2144664904 cites W2119508007 @default.
• W2144664904 cites W2121166356 @default.
• W2144664904 cites W2125659471 @default.
• W2144664904 cites W2126032465 @default.
• W2144664904 cites W2126192987 @default.
• W2144664904 cites W2134105090 @default.
• W2144664904 cites W2140412307 @default.
• W2144664904 cites W2163839619 @default.
• W2144664904 cites W2165199383 @default.
• W2144664904 cites W2169660887 @default.
• W2144664904 cites W2170588662 @default.
• W2144664904 cites W2171498721 @default.
• W2144664904 doi "https://doi.org/10.2337/db10-1361" @default.
• W2144664904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3046857" @default.
• W2144664904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21270242" @default.
• W2144664904 hasPublicationYear "2011" @default.
• W2144664904 type Work @default.
• W2144664904 sameAs 2144664904 @default.
• W2144664904 citedByCount "65" @default.
• W2144664904 countsByYear W21446649042012 @default.
• W2144664904 countsByYear W21446649042013 @default.
• W2144664904 countsByYear W21446649042014 @default.
• W2144664904 countsByYear W21446649042015 @default.
• W2144664904 countsByYear W21446649042016 @default.
• W2144664904 countsByYear W21446649042017 @default.
• W2144664904 countsByYear W21446649042018 @default.
• W2144664904 countsByYear W21446649042019 @default.
• W2144664904 countsByYear W21446649042020 @default.
• W2144664904 countsByYear W21446649042021 @default.
• W2144664904 countsByYear W21446649042022 @default.
• W2144664904 countsByYear W21446649042023 @default.
• W2144664904 crossrefType "journal-article" @default.
• W2144664904 hasAuthorship W2144664904A5003430784 @default.
• W2144664904 hasAuthorship W2144664904A5007276836 @default.
• W2144664904 hasAuthorship W2144664904A5010378457 @default.
• W2144664904 hasAuthorship W2144664904A5032191719 @default.
• W2144664904 hasAuthorship W2144664904A5033338291 @default.
• W2144664904 hasAuthorship W2144664904A5039655833 @default.
• W2144664904 hasAuthorship W2144664904A5040159416 @default.
• W2144664904 hasAuthorship W2144664904A5080291594 @default.
• W2144664904 hasAuthorship W2144664904A5089180594 @default.
• W2144664904 hasBestOaLocation W21446649041 @default.
• W2144664904 hasConcept C126322002 @default.
• W2144664904 hasConcept C134018914 @default.
• W2144664904 hasConcept C170493617 @default.
• W2144664904 hasConcept C185592680 @default.
• W2144664904 hasConcept C187345961 @default.
• W2144664904 hasConcept C2777391703 @default.
• W2144664904 hasConcept C2778938600 @default.
• W2144664904 hasConcept C2779280383 @default.
• W2144664904 hasConcept C2779922275 @default.
• W2144664904 hasConcept C2780804394 @default.
• W2144664904 hasConcept C555293320 @default.
• W2144664904 hasConcept C71924100 @default.
• W2144664904 hasConcept C7341990 @default.
• W2144664904 hasConceptScore W2144664904C126322002 @default.
• W2144664904 hasConceptScore W2144664904C134018914 @default.
• W2144664904 hasConceptScore W2144664904C170493617 @default.
• W2144664904 hasConceptScore W2144664904C185592680 @default.
• W2144664904 hasConceptScore W2144664904C187345961 @default.
• W2144664904 hasConceptScore W2144664904C2777391703 @default.
• W2144664904 hasConceptScore W2144664904C2778938600 @default.

• next