Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144667070> ?p ?o ?g. }
- W2144667070 endingPage "1310" @default.
- W2144667070 startingPage "1305" @default.
- W2144667070 abstract "Abstract IL-10 IFNγ-secreting CD4+ T cells are suppressive T cells able to inhibit cytotoxic T lymphocyte regulated by several signal pathways and have therapeutic implication for infectious diseases and autoimmune diseases. IL-10 IFN-γ-secreting CD4+ T cells were first found in the early 1990s. They are suppressive T cells able to inhibit cytotoxic T lymphocytes. These cells (Foxp3–T bet+) have a similar function but are distinct from conventional Tregs. The production of IL-10 in these cells requires IL-27 and TGF-β and was regulated by several signal pathways including Notch, STAT, and NF-κB. The crosstalk among these pathways is critical for the generation and function of these cells. IL-10 IFN-γ-secreting CD4+ T cells are activated in chronic infection and are responsible for prolonged infection. Thus, their modulation has therapeutic implications for the treatment of infectious diseases. However, it is complicated, and fine-tuning of IFN-γ and IL-10 secretion by these cells is needed for disease management, as inhibition of these cells will also lead to overimmune responses. On the other hand, increasing their numbers in autoimmune diseases may have beneficial effects." @default.
- W2144667070 created "2016-06-24" @default.
- W2144667070 creator A5043991326 @default.
- W2144667070 creator A5058107287 @default.
- W2144667070 date "2009-09-09" @default.
- W2144667070 modified "2023-09-27" @default.
- W2144667070 title "Development and function of IL-10 IFN-γ-secreting CD4+ T cells" @default.
- W2144667070 cites W1484840368 @default.
- W2144667070 cites W1488126231 @default.
- W2144667070 cites W1489445152 @default.
- W2144667070 cites W1496007453 @default.
- W2144667070 cites W1510730676 @default.
- W2144667070 cites W1545910465 @default.
- W2144667070 cites W1649938880 @default.
- W2144667070 cites W1931329582 @default.
- W2144667070 cites W1942794504 @default.
- W2144667070 cites W1969744540 @default.
- W2144667070 cites W1973007471 @default.
- W2144667070 cites W1974781378 @default.
- W2144667070 cites W1982664065 @default.
- W2144667070 cites W1985621901 @default.
- W2144667070 cites W1986148978 @default.
- W2144667070 cites W1990120079 @default.
- W2144667070 cites W1993302385 @default.
- W2144667070 cites W1997089052 @default.
- W2144667070 cites W1998077939 @default.
- W2144667070 cites W1999561404 @default.
- W2144667070 cites W2004660702 @default.
- W2144667070 cites W2008998437 @default.
- W2144667070 cites W2010204335 @default.
- W2144667070 cites W2011319298 @default.
- W2144667070 cites W2014859793 @default.
- W2144667070 cites W2026286437 @default.
- W2144667070 cites W2034589667 @default.
- W2144667070 cites W2039376771 @default.
- W2144667070 cites W2047782528 @default.
- W2144667070 cites W2047820200 @default.
- W2144667070 cites W2048399113 @default.
- W2144667070 cites W2054517109 @default.
- W2144667070 cites W2054973241 @default.
- W2144667070 cites W2059122129 @default.
- W2144667070 cites W2061021775 @default.
- W2144667070 cites W2064164196 @default.
- W2144667070 cites W2074006404 @default.
- W2144667070 cites W2082734149 @default.
- W2144667070 cites W2084990572 @default.
- W2144667070 cites W2093457368 @default.
- W2144667070 cites W2095804489 @default.
- W2144667070 cites W2097021075 @default.
- W2144667070 cites W2103180268 @default.
- W2144667070 cites W2103235243 @default.
- W2144667070 cites W2103904373 @default.
- W2144667070 cites W2109720288 @default.
- W2144667070 cites W2114357202 @default.
- W2144667070 cites W2116394003 @default.
- W2144667070 cites W2116723397 @default.
- W2144667070 cites W2127303484 @default.
- W2144667070 cites W2130253814 @default.
- W2144667070 cites W2133943800 @default.
- W2144667070 cites W2136097155 @default.
- W2144667070 cites W2138718238 @default.
- W2144667070 cites W2152532651 @default.
- W2144667070 cites W2153795402 @default.
- W2144667070 cites W2158488680 @default.
- W2144667070 cites W2159013483 @default.
- W2144667070 cites W2161074777 @default.
- W2144667070 cites W2167775985 @default.
- W2144667070 cites W2171435138 @default.
- W2144667070 cites W2332018470 @default.
- W2144667070 cites W4255434743 @default.
- W2144667070 cites W4313308310 @default.
- W2144667070 cites W4321429568 @default.
- W2144667070 doi "https://doi.org/10.1189/jlb.0609406" @default.
- W2144667070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19741156" @default.
- W2144667070 hasPublicationYear "2009" @default.
- W2144667070 type Work @default.
- W2144667070 sameAs 2144667070 @default.
- W2144667070 citedByCount "36" @default.
- W2144667070 countsByYear W21446670702012 @default.
- W2144667070 countsByYear W21446670702013 @default.
- W2144667070 countsByYear W21446670702014 @default.
- W2144667070 countsByYear W21446670702015 @default.
- W2144667070 countsByYear W21446670702016 @default.
- W2144667070 countsByYear W21446670702017 @default.
- W2144667070 countsByYear W21446670702019 @default.
- W2144667070 countsByYear W21446670702021 @default.
- W2144667070 countsByYear W21446670702022 @default.
- W2144667070 crossrefType "journal-article" @default.
- W2144667070 hasAuthorship W2144667070A5043991326 @default.
- W2144667070 hasAuthorship W2144667070A5058107287 @default.
- W2144667070 hasConcept C129374314 @default.
- W2144667070 hasConcept C149532602 @default.
- W2144667070 hasConcept C154317977 @default.
- W2144667070 hasConcept C202751555 @default.
- W2144667070 hasConcept C203014093 @default.
- W2144667070 hasConcept C2776090121 @default.
- W2144667070 hasConcept C2779727006 @default.
- W2144667070 hasConcept C55493867 @default.