FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144674130> ?p ?o ?g. }

• W2144674130 endingPage "251" @default.
• W2144674130 startingPage "247" @default.
• W2144674130 abstract "In the metastatic process, proteolytic enzymes play an important role in mediating the passage of cancer cells through the basement membrane and extracellular matrix. We have compared cathepsin-D (CD) expression in a range of benign and malignant breast lesions so as to investigate its role in breast cancer progression. One hundred and sixty-two breast samples, comprising 18 fibroadenomas, 22 fibrocystic disease, 96 invasive ductal carcinoma and 26 lesions with intraductal carcinoma components, were evaluated for CD expression by the standard avidin-biotin-immunoperoxidase complex method on formalin-fixed, paraffin-embedded histological sections using a commercial antibody against human cathepsin-D. Of the invasive ductal carcinomas, 61.5% showed stromal cell CD positivity, whereas 48.9% expressed CD positivity in neoplastic cells. There was significant correlation between neoplastic cell and stromal CD positivity. The prevalences of CD positivity in both neoplastic and stromal cell components were significantly higher (P < 0.05 and P < 0.01, respectively) in histological grade III tumors compared to grades I and II carcinomas. CD expression by either neoplastic or stromal cells did not show significant correlation with patient age and tumor size. Only 15% of intraductal carcinomas were CD positive and expression was limited to neoplastic cells. Neither epithelial nor stromal cells in fibrocystic lesions and fibroadenomas were CD positive, but a weak to moderate positivity was observed within myoepithelial cells in mammary ducts. These findings provide insights into the mechanism whereby tumors with high histological grade mediate invasion into tissue. The role of stromal cells in tumor progression and the means of their recruitment deserve further study." @default.
• W2144674130 created "2016-06-24" @default.
• W2144674130 creator A5005236363 @default.
• W2144674130 creator A5041724163 @default.
• W2144674130 creator A5059080833 @default.
• W2144674130 date "1999-01-01" @default.
• W2144674130 modified "2023-10-10" @default.
• W2144674130 title "A comparison of the pattern of cathepsin-D expression in fibroadenoma, fibrocystic disease, preinvasive and invasive ductal breast carcinoma" @default.
• W2144674130 cites W1498027545 @default.
• W2144674130 cites W1523426469 @default.
• W2144674130 cites W1817657028 @default.
• W2144674130 cites W1963579325 @default.
• W2144674130 cites W1975717886 @default.
• W2144674130 cites W1983060551 @default.
• W2144674130 cites W1987829945 @default.
• W2144674130 cites W1990491336 @default.
• W2144674130 cites W1990494772 @default.
• W2144674130 cites W1994089929 @default.
• W2144674130 cites W2003692285 @default.
• W2144674130 cites W2005564654 @default.
• W2144674130 cites W2005617198 @default.
• W2144674130 cites W2008042551 @default.
• W2144674130 cites W2023442779 @default.
• W2144674130 cites W2040544941 @default.
• W2144674130 cites W2041633573 @default.
• W2144674130 cites W2051922225 @default.
• W2144674130 cites W2071680839 @default.
• W2144674130 cites W2073452143 @default.
• W2144674130 cites W2074267857 @default.
• W2144674130 cites W2076125248 @default.
• W2144674130 cites W2092018283 @default.
• W2144674130 cites W2094504380 @default.
• W2144674130 cites W2131232241 @default.
• W2144674130 cites W2326165980 @default.
• W2144674130 doi "https://doi.org/10.1080/003130299105061" @default.
• W2144674130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11523929" @default.
• W2144674130 hasPublicationYear "1999" @default.
• W2144674130 type Work @default.
• W2144674130 sameAs 2144674130 @default.
• W2144674130 citedByCount "7" @default.
• W2144674130 crossrefType "journal-article" @default.
• W2144674130 hasAuthorship W2144674130A5005236363 @default.
• W2144674130 hasAuthorship W2144674130A5041724163 @default.
• W2144674130 hasAuthorship W2144674130A5059080833 @default.
• W2144674130 hasConcept C121608353 @default.
• W2144674130 hasConcept C126322002 @default.
• W2144674130 hasConcept C128102431 @default.
• W2144674130 hasConcept C140884156 @default.
• W2144674130 hasConcept C142724271 @default.
• W2144674130 hasConcept C159654299 @default.
• W2144674130 hasConcept C16930146 @default.
• W2144674130 hasConcept C203014093 @default.
• W2144674130 hasConcept C204232928 @default.
• W2144674130 hasConcept C2776524808 @default.
• W2144674130 hasConcept C2778148616 @default.
• W2144674130 hasConcept C2779013556 @default.
• W2144674130 hasConcept C2780567641 @default.
• W2144674130 hasConcept C2780862961 @default.
• W2144674130 hasConcept C502942594 @default.
• W2144674130 hasConcept C530470458 @default.
• W2144674130 hasConcept C542903549 @default.
• W2144674130 hasConcept C71924100 @default.
• W2144674130 hasConcept C86803240 @default.
• W2144674130 hasConceptScore W2144674130C121608353 @default.
• W2144674130 hasConceptScore W2144674130C126322002 @default.
• W2144674130 hasConceptScore W2144674130C128102431 @default.
• W2144674130 hasConceptScore W2144674130C140884156 @default.
• W2144674130 hasConceptScore W2144674130C142724271 @default.
• W2144674130 hasConceptScore W2144674130C159654299 @default.
• W2144674130 hasConceptScore W2144674130C16930146 @default.
• W2144674130 hasConceptScore W2144674130C203014093 @default.
• W2144674130 hasConceptScore W2144674130C204232928 @default.
• W2144674130 hasConceptScore W2144674130C2776524808 @default.
• W2144674130 hasConceptScore W2144674130C2778148616 @default.
• W2144674130 hasConceptScore W2144674130C2779013556 @default.
• W2144674130 hasConceptScore W2144674130C2780567641 @default.
• W2144674130 hasConceptScore W2144674130C2780862961 @default.
• W2144674130 hasConceptScore W2144674130C502942594 @default.
• W2144674130 hasConceptScore W2144674130C530470458 @default.
• W2144674130 hasConceptScore W2144674130C542903549 @default.
• W2144674130 hasConceptScore W2144674130C71924100 @default.
• W2144674130 hasConceptScore W2144674130C86803240 @default.
• W2144674130 hasIssue "3" @default.
• W2144674130 hasLocation W21446741301 @default.
• W2144674130 hasLocation W21446741302 @default.
• W2144674130 hasOpenAccess W2144674130 @default.
• W2144674130 hasPrimaryLocation W21446741301 @default.
• W2144674130 hasRelatedWork W1973446725 @default.
• W2144674130 hasRelatedWork W2056010278 @default.
• W2144674130 hasRelatedWork W2063113938 @default.
• W2144674130 hasRelatedWork W2063208238 @default.
• W2144674130 hasRelatedWork W2068196594 @default.
• W2144674130 hasRelatedWork W2389247214 @default.
• W2144674130 hasRelatedWork W2420147744 @default.
• W2144674130 hasRelatedWork W2567216403 @default.
• W2144674130 hasRelatedWork W3086577161 @default.
• W2144674130 hasRelatedWork W3127911401 @default.
• W2144674130 hasVolume "31" @default.

• next