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• W2144682743 abstract "Nontypeable Haemophilus influenzae often causes exacerbations of chronic obstructive pulmonary disease (COPD), and these exacerbations are frequently treated with oral antibiotics. The goals of this study were to determine the frequency of the simultaneous presence of multiple strains of H. influenzae in sputum and to measure the MICs of antibiotics for the isolates. In a prospective study, adults with COPD were seen monthly. Sputum cultures were obtained, and individual colonies were subjected to genomic DNA typing and MIC determinations. Multiple strains of H. influenzae were present simultaneously in the sputum of 26.3% of adults with COPD. In 64.5% of these, MICs of >/=1 antibiotic varied by >/=4-fold among the strains. Therefore, multiple strains of H. influenzae are frequently present simultaneously in the sputum of adults with COPD, and the antimicrobial susceptibility of different strains in the same sputum sometimes differs." @default.
• W2144682743 created "2016-06-24" @default.
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• W2144682743 date "1999-08-01" @default.
• W2144682743 modified "2023-10-10" @default.
• W2144682743 title "Simultaneous Respiratory Tract Colonization by Multiple Strains of Nontypeable<i>Haemophilus influenzae</i>in Chronic Obstructive Pulmonary Disease: Implications for Antibiotic Therapy" @default.
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• W2144682743 doi "https://doi.org/10.1086/314870" @default.
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