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• W2144702953 startingPage "5048" @default.
• W2144702953 abstract "One obvious phenotype of tumor cells is the lack of terminal differentiation. We previously classified rhabdomyosarcoma cell lines as having either a recessive or a dominant nondifferentiating phenotype. To study the genetic basis of the dominant nondifferentiating phenotype, we utilized microcell fusion to transfer chromosomes from rhabdomyosarcoma cells into C2C12 myoblasts. Transfer of a derivative chromosome 14 inhibits differentiation. The derivative chromosome 14 contains a DNA amplification. MDM2 is amplified and overexpressed in these nondifferentiating hybrids and in the parental rhabdomyosarcoma. Forced expression of MDM2 inhibits MyoD-dependent transcription. Expression of antisense MDM2 restores MyoD-dependent transcriptional activity. We conclude that amplification and overexpression of MDM2 inhibit MyoD function, resulting in a dominant nondifferentiating phenotype." @default.
• W2144702953 created "2016-06-24" @default.
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• W2144702953 date "1996-09-01" @default.
• W2144702953 modified "2023-10-01" @default.
• W2144702953 title "Amplification of <i>MDM2</i> Inhibits MyoD-Mediated Myogenesis" @default.
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• W2144702953 doi "https://doi.org/10.1128/mcb.16.9.5048" @default.
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