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- W2144713899 abstract "Progressive stiffening of collagen tissue by bioapatite mineral is important physiologically, but the details of this stiffening are uncertain. Unresolved questions about the details of the accommodation of bioapatite within and upon collagen's hierarchical structure have posed a central hurdle, but recent microscopy data resolve several major questions. These data suggest how collagen accommodates bioapatite at the lowest relevant hierarchical level (collagen fibrils), and suggest several possibilities for the progressive accommodation of bioapatite at higher hierarchical length scales (fibres and tissue). We developed approximations for the stiffening of collagen across spatial hierarchies based upon these data, and connected models across hierarchies levels to estimate mineralization-dependent tissue-level mechanics. In the five possible sequences of mineralization studied, percolation of the bioapatite phase proved to be an important determinant of the degree of stiffening by bioapatite. The models were applied to study one important instance of partially mineralized tissue, which occurs at the attachment of tendon to bone. All sequences of mineralization considered reproduced experimental observations of a region of tissue between tendon and bone that is more compliant than either tendon or bone, but the size and nature of this region depended strongly upon the sequence of mineralization. These models and observations have implications for engineered tissue scaffolds at the attachment of tendon to bone, bone development and graded biomimetic attachment of dissimilar hierarchical materials in general." @default.
- W2144713899 created "2016-06-24" @default.
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- W2144713899 date "2014-03-06" @default.
- W2144713899 modified "2023-10-09" @default.
- W2144713899 title "Modelling the mechanics of partially mineralized collagen fibrils, fibres and tissue" @default.
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- W2144713899 doi "https://doi.org/10.1098/rsif.2013.0835" @default.
- W2144713899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3899858" @default.
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