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- W2144730566 abstract "The serum level of high-density lipoprotein cholesterol (HDL-c), which protects against the development of atherosclerosis, is under genetic control. However, the genetic components responsible for the serum HDL-c level are yet to be determined. A recent knockout mouse study demonstrated that hepatocyte nuclear factor-1α (HNF-1α) is an essential transcriptional regulator of HDL-c metabolism. In this study, the association of an HNF-1α gene polymorphism, isoleucine (Ile) 27 leucine (Leu), with lipid parameters, in particular with serum HDL-c level, was studied in 356 unrelated Japanese men. Though no significant difference was observed in total cholesterol and triglyceride levels among the three genotypes, the serum HDL-c level was significantly associated with the genotype (P < 0.01, trend test). Subjects with the Ile/Ile genotype had low serum HDL-c levels, and those with the Leu/Leu genotype had high serum HDL-c levels. These results demonstrate that the HNF-1α gene locus is associated with serum HDL-c level and suggest that the Ile27 allele is a risk marker for atherosclerosis." @default.
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- W2144730566 date "2003-06-01" @default.
- W2144730566 modified "2023-10-02" @default.
- W2144730566 title "Association of I27L Polymorphism of Hepatocyte Nuclear Factor-1α Gene with High-Density Lipoprotein Cholesterol Level" @default.
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- W2144730566 doi "https://doi.org/10.1210/jc.2002-021891" @default.
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