FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144798678> ?p ?o ?g. }

• W2144798678 endingPage "e1002777" @default.
• W2144798678 startingPage "e1002777" @default.
• W2144798678 abstract "The centromere is a functional chromosome domain that is essential for faithful chromosome segregation during cell division and that can be reliably identified by the presence of the centromere-specific histone H3 variant CenH3. In monocentric chromosomes, the centromere is characterized by a single CenH3-containing region within a morphologically distinct primary constriction. This region usually spans up to a few Mbp composed mainly of centromere-specific satellite DNA common to all chromosomes of a given species. In holocentric chromosomes, there is no primary constriction; the centromere is composed of many CenH3 loci distributed along the entire length of a chromosome. Using correlative fluorescence light microscopy and high-resolution electron microscopy, we show that pea (Pisum sativum) chromosomes exhibit remarkably long primary constrictions that contain 3-5 explicit CenH3-containing regions, a novelty in centromere organization. In addition, we estimate that the size of the chromosome segment delimited by two outermost domains varies between 69 Mbp and 107 Mbp, several factors larger than any known centromere length. These domains are almost entirely composed of repetitive DNA sequences belonging to 13 distinct families of satellite DNA and one family of centromeric retrotransposons, all of which are unevenly distributed among pea chromosomes. We present the centromeres of Pisum as novel meta-polycentric functional domains. Our results demonstrate that the organization and DNA composition of functional centromere domains can be far more complex than previously thought, do not require single repetitive elements, and do not require single centromere domains in order to segregate properly. Based on these findings, we propose Pisum as a useful model for investigation of centromere architecture and the still poorly understood role of repetitive DNA in centromere evolution, determination, and function." @default.
• W2144798678 created "2016-06-24" @default.
• W2144798678 creator A5021448726 @default.
• W2144798678 creator A5022850536 @default.
• W2144798678 creator A5040083768 @default.
• W2144798678 creator A5044567919 @default.
• W2144798678 creator A5051110217 @default.
• W2144798678 creator A5069666827 @default.
• W2144798678 creator A5074864948 @default.
• W2144798678 creator A5074879289 @default.
• W2144798678 creator A5091456240 @default.
• W2144798678 date "2012-06-21" @default.
• W2144798678 modified "2023-10-02" @default.
• W2144798678 title "Stretching the Rules: Monocentric Chromosomes with Multiple Centromere Domains" @default.
• W2144798678 cites W1491559418 @default.
• W2144798678 cites W1961098066 @default.
• W2144798678 cites W1971990935 @default.
• W2144798678 cites W1975719737 @default.
• W2144798678 cites W1994480624 @default.
• W2144798678 cites W2002581734 @default.
• W2144798678 cites W2003650349 @default.
• W2144798678 cites W2005673947 @default.
• W2144798678 cites W20126109 @default.
• W2144798678 cites W2013257559 @default.
• W2144798678 cites W2016704962 @default.
• W2144798678 cites W2021692957 @default.
• W2144798678 cites W2029920510 @default.
• W2144798678 cites W2031006817 @default.
• W2144798678 cites W2031904316 @default.
• W2144798678 cites W2051866505 @default.
• W2144798678 cites W2056470976 @default.
• W2144798678 cites W2064512698 @default.
• W2144798678 cites W2065961884 @default.
• W2144798678 cites W2075237579 @default.
• W2144798678 cites W2077877588 @default.
• W2144798678 cites W2078534178 @default.
• W2144798678 cites W2083993958 @default.
• W2144798678 cites W2100131369 @default.
• W2144798678 cites W2113074959 @default.
• W2144798678 cites W2123364539 @default.
• W2144798678 cites W2124154896 @default.
• W2144798678 cites W2124719292 @default.
• W2144798678 cites W2125516884 @default.
• W2144798678 cites W2133218990 @default.
• W2144798678 cites W2136171191 @default.
• W2144798678 cites W2157537668 @default.
• W2144798678 cites W2157793771 @default.
• W2144798678 cites W2160636499 @default.
• W2144798678 cites W24036813 @default.
• W2144798678 cites W4230501579 @default.
• W2144798678 doi "https://doi.org/10.1371/journal.pgen.1002777" @default.
• W2144798678 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3380829" @default.
• W2144798678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22737088" @default.
• W2144798678 hasPublicationYear "2012" @default.
• W2144798678 type Work @default.
• W2144798678 sameAs 2144798678 @default.
• W2144798678 citedByCount "112" @default.
• W2144798678 countsByYear W21447986782012 @default.
• W2144798678 countsByYear W21447986782013 @default.
• W2144798678 countsByYear W21447986782014 @default.
• W2144798678 countsByYear W21447986782015 @default.
• W2144798678 countsByYear W21447986782016 @default.
• W2144798678 countsByYear W21447986782017 @default.
• W2144798678 countsByYear W21447986782018 @default.
• W2144798678 countsByYear W21447986782019 @default.
• W2144798678 countsByYear W21447986782020 @default.
• W2144798678 countsByYear W21447986782021 @default.
• W2144798678 countsByYear W21447986782022 @default.
• W2144798678 countsByYear W21447986782023 @default.
• W2144798678 crossrefType "journal-article" @default.
• W2144798678 hasAuthorship W2144798678A5021448726 @default.
• W2144798678 hasAuthorship W2144798678A5022850536 @default.
• W2144798678 hasAuthorship W2144798678A5040083768 @default.
• W2144798678 hasAuthorship W2144798678A5044567919 @default.
• W2144798678 hasAuthorship W2144798678A5051110217 @default.
• W2144798678 hasAuthorship W2144798678A5069666827 @default.
• W2144798678 hasAuthorship W2144798678A5074864948 @default.
• W2144798678 hasAuthorship W2144798678A5074879289 @default.
• W2144798678 hasAuthorship W2144798678A5091456240 @default.
• W2144798678 hasBestOaLocation W21447986781 @default.
• W2144798678 hasConcept C104317684 @default.
• W2144798678 hasConcept C140367098 @default.
• W2144798678 hasConcept C141231307 @default.
• W2144798678 hasConcept C169802333 @default.
• W2144798678 hasConcept C30481170 @default.
• W2144798678 hasConcept C54355233 @default.
• W2144798678 hasConcept C63491729 @default.
• W2144798678 hasConcept C78458016 @default.
• W2144798678 hasConcept C86803240 @default.
• W2144798678 hasConceptScore W2144798678C104317684 @default.
• W2144798678 hasConceptScore W2144798678C140367098 @default.
• W2144798678 hasConceptScore W2144798678C141231307 @default.
• W2144798678 hasConceptScore W2144798678C169802333 @default.
• W2144798678 hasConceptScore W2144798678C30481170 @default.
• W2144798678 hasConceptScore W2144798678C54355233 @default.
• W2144798678 hasConceptScore W2144798678C63491729 @default.
• W2144798678 hasConceptScore W2144798678C78458016 @default.
• W2144798678 hasConceptScore W2144798678C86803240 @default.

• next