FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144804953> ?p ?o ?g. }

• W2144804953 endingPage "E26" @default.
• W2144804953 startingPage "E21" @default.
• W2144804953 abstract "Bipolar disorder is a common psychiatric mood disorder that is defined by recurrent episodes of abnormally elevated mood and depression. Progressive structural brain changes in individuals with bipolar disorder have been suggested to be associated with defects in the secretion of neurotrophic factors. We sought to assess how the regulated secretory pathway in the brain is affected in patients with bipolar disorder by measuring chromogranin B and secretogranin II, which are 2 cerebrospinal fluid (CSF) biological markers for this process.We measured the concentrations of chromogranin B (peptide 439-451) and secretogranin II (peptide 154-165) in the CSF of patients with well-defined bipolar disorder and healthy controls. The lifetime severity of bipolar disorder was rated using the Clinical Global Impression (CGI) scale.We included 126 patients with bipolar disorder and 71 healthy controls in our analysis. Concentrations of secretogranin II were significantly lower in patients with bipolar disorder type I than in healthy controls. The reduction was most pronounced in patients with high CGI scores (i.e., severe disease).The cross-sectional design of the current study limits the ability to pinpoint the causalities behind the observed associations.This study shows that the CSF marker secretogranin II has the potential to act as a biological marker for severe forms of bipolar disorder. Our findings indicate that patients with bipolar disorder possess defects in the regulatory secretory pathway, which may be of relevance to the progressive structural brain changes seen in those with severe forms of the disease." @default.
• W2144804953 created "2016-06-24" @default.
• W2144804953 creator A5023024313 @default.
• W2144804953 creator A5025313057 @default.
• W2144804953 creator A5045856839 @default.
• W2144804953 creator A5049944079 @default.
• W2144804953 creator A5054475759 @default.
• W2144804953 creator A5063282531 @default.
• W2144804953 creator A5065013242 @default.
• W2144804953 creator A5079766290 @default.
• W2144804953 date "2013-06-01" @default.
• W2144804953 modified "2023-10-12" @default.
• W2144804953 title "Decreased cerebrospinal fluid secretogranin II concentrations in severe forms of bipolar disorder" @default.
• W2144804953 cites W1600943356 @default.
• W2144804953 cites W1888302320 @default.
• W2144804953 cites W1897434226 @default.
• W2144804953 cites W1964162654 @default.
• W2144804953 cites W1966048742 @default.
• W2144804953 cites W1968531119 @default.
• W2144804953 cites W1970019957 @default.
• W2144804953 cites W1970082985 @default.
• W2144804953 cites W1970528183 @default.
• W2144804953 cites W1971590607 @default.
• W2144804953 cites W1972463315 @default.
• W2144804953 cites W1973652904 @default.
• W2144804953 cites W1980992032 @default.
• W2144804953 cites W1981077350 @default.
• W2144804953 cites W1981322456 @default.
• W2144804953 cites W1983037351 @default.
• W2144804953 cites W1984344128 @default.
• W2144804953 cites W1985009927 @default.
• W2144804953 cites W1995051494 @default.
• W2144804953 cites W1999943287 @default.
• W2144804953 cites W2001058095 @default.
• W2144804953 cites W2001836961 @default.
• W2144804953 cites W2005097835 @default.
• W2144804953 cites W2015011211 @default.
• W2144804953 cites W2019465651 @default.
• W2144804953 cites W2027263993 @default.
• W2144804953 cites W2028681480 @default.
• W2144804953 cites W2029305015 @default.
• W2144804953 cites W2032466141 @default.
• W2144804953 cites W2037995604 @default.
• W2144804953 cites W2040952671 @default.
• W2144804953 cites W2048335778 @default.
• W2144804953 cites W2052873699 @default.
• W2144804953 cites W2063542959 @default.
• W2144804953 cites W2069225280 @default.
• W2144804953 cites W2071378588 @default.
• W2144804953 cites W2073678037 @default.
• W2144804953 cites W2081730310 @default.
• W2144804953 cites W2082069345 @default.
• W2144804953 cites W2082621302 @default.
• W2144804953 cites W2082808083 @default.
• W2144804953 cites W2096936673 @default.
• W2144804953 cites W2098597355 @default.
• W2144804953 cites W2107523578 @default.
• W2144804953 cites W2110608362 @default.
• W2144804953 cites W2113823824 @default.
• W2144804953 cites W2123065833 @default.
• W2144804953 cites W2123412124 @default.
• W2144804953 cites W2131823335 @default.
• W2144804953 cites W2142476463 @default.
• W2144804953 cites W2150464881 @default.
• W2144804953 cites W2167659819 @default.
• W2144804953 cites W3134891749 @default.
• W2144804953 cites W2245231029 @default.
• W2144804953 doi "https://doi.org/10.1503/jpn.120170" @default.
• W2144804953 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3692729" @default.
• W2144804953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23415276" @default.
• W2144804953 hasPublicationYear "2013" @default.
• W2144804953 type Work @default.
• W2144804953 sameAs 2144804953 @default.
• W2144804953 citedByCount "13" @default.
• W2144804953 countsByYear W21448049532014 @default.
• W2144804953 countsByYear W21448049532015 @default.
• W2144804953 countsByYear W21448049532016 @default.
• W2144804953 countsByYear W21448049532017 @default.
• W2144804953 countsByYear W21448049532018 @default.
• W2144804953 countsByYear W21448049532019 @default.
• W2144804953 countsByYear W21448049532020 @default.
• W2144804953 countsByYear W21448049532023 @default.
• W2144804953 crossrefType "journal-article" @default.
• W2144804953 hasAuthorship W2144804953A5023024313 @default.
• W2144804953 hasAuthorship W2144804953A5025313057 @default.
• W2144804953 hasAuthorship W2144804953A5045856839 @default.
• W2144804953 hasAuthorship W2144804953A5049944079 @default.
• W2144804953 hasAuthorship W2144804953A5054475759 @default.
• W2144804953 hasAuthorship W2144804953A5063282531 @default.
• W2144804953 hasAuthorship W2144804953A5065013242 @default.
• W2144804953 hasAuthorship W2144804953A5079766290 @default.
• W2144804953 hasBestOaLocation W21448049531 @default.
• W2144804953 hasConcept C118552586 @default.
• W2144804953 hasConcept C126322002 @default.
• W2144804953 hasConcept C134018914 @default.
• W2144804953 hasConcept C15744967 @default.
• W2144804953 hasConcept C204232928 @default.
• W2144804953 hasConcept C2776174506 @default.

• next