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• W2144827439 endingPage "1134" @default.
• W2144827439 startingPage "1131" @default.
• W2144827439 abstract "Beat It Primary cilia are specialized organelles that serve important sensory functions in many different tissues and cells, and defects in their structure and function underlie a variety of genetic diseases. In contrast to primary cilia, motile cilia serve a mechanical function. For example, the cilia on airway epithelia remove inhaled material from the lung. Shah et al. (p. 1131 , published online 23 July; see the cover; see the Perspective by Kinnamon and Reynolds ) now show that these classic motile cilia are also chemosensory. The motile cilia on airway epithelia contain bitter-taste receptors and their associated signaling machinery. Moreover, application of bitter substances triggers an elevation of intracellular Ca 2+ levels and increases cilia beat frequency. Thus, in airway epithelia, bitter-taste receptors may be able to detect noxious substances entering the airways and initiate an autonomous defensive mechanism designed to accelerate elimination of the offending compound." @default.
• W2144827439 created "2016-06-24" @default.
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• W2144827439 date "2009-08-28" @default.
• W2144827439 modified "2023-10-17" @default.
• W2144827439 title "Motile Cilia of Human Airway Epithelia Are Chemosensory" @default.
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• W2144827439 doi "https://doi.org/10.1126/science.1173869" @default.
• W2144827439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2894709" @default.
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