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• W2144829286 abstract "AbstractThe La protein is a target of autoantibodies in patients suffering from Sjögren's syndrome, systemic lupus erythematosus, and neonatal lupus. Ubiquitous in eukaryotes, La functions as a RNA-binding protein that promotes the maturation of tRNA precursors and other nascent transcripts synthesized by RNA polymerase III as well as other noncoding RNAs. La also associates with a class of mRNAs that encode ribosome subunits and precursors to snoRNAs involved in ribosome biogenesis. Thus, it was surprising that La is dispensable in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, the organisms from which it has been characterized most extensively. To determine whether La is essential in mammals and if so, at which developmental stage it is required, mice were created with a disrupted La gene, and the offspring from La+/ −intercrosses were analyzed. La − / − offspring were detected at the expected frequency among blastocysts prior to implantation, whereas no nullizygotes were detected after implantation, indicating that La is required early in development. Blastocysts derived from La +/ − intercrosses yielded 38 La +/+ and La +/ − embryonic stem (ES) cell lines but no La − / − ES cell lines, suggesting that La contributes a critical function toward the establishment or survival of ES cells. Consistent with this, La − / − blastocyst outgrowths revealed loss of the inner cell mass (ICM). The results indicate that in contrast to the situation in yeasts, La is essential in mammals and is one of a limited number of genes required as early as the development of the ICM. We thank Jack Keene (Duke University) for patient anti-La sera and to R. Crouch and E. Frolova (NICHD) for help with embryo isolation. We are grateful to the NICHD Animal Use Committee, the 6B animal facility, and the NIH Pathology Service.This research was supported by the Intramural Research Program of NICHD, NIH. R.J.M. is a Commissioned Officer in the U.S. Public Health Service." @default.
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• W2144829286 date "2006-02-01" @default.
• W2144829286 modified "2023-10-16" @default.
• W2144829286 title "The Multifunctional RNA-Binding Protein La Is Required for Mouse Development and for the Establishment of EmbryonicStem Cells" @default.
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• W2144829286 doi "https://doi.org/10.1128/mcb.26.4.1445-1451.2006" @default.
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