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• W2144861653 abstract "The oligonucleotide r(GGACUUCGGUCC) has been observed to adopt a hairpin conformation by solution NMR and a double helical conformation by X-ray diffraction. In order to understand this apparent conflict, we used time-resolved fluorescence depolarization and 19 fluorine NMR to follow the secondary structure of this dodecamer as the solution composition was changed stepwise from the NMR experimental conditions to those used for crystallization. Calculation of the dodecamer concentration in the crystal (180 mM strands) and the cation concentration needed for neutrality (>2 M) prompted investigation of a tethered species, in which two dodecamers are connected by a string of 4 nt, geometrically equivalent to ∼100 mM strands, in 2.5 M NaCl. The RNA tetraloop and its DNA analog maintain a single-strand hairpin conformation in solution, even under the conditions used to grow the crystal. Under high salt conditions, the tethered RNA and DNA analogs of this sequence yield secondary components which could be the double helical conformation. Crystal contacts in addition to solvent changes and high RNA concentrations are needed to obtain the double helix as the predominant species." @default.
• W2144861653 created "2016-06-24" @default.
• W2144861653 creator A5033467844 @default.
• W2144861653 date "1996-10-15" @default.
• W2144861653 modified "2023-09-27" @default.
• W2144861653 title "Secondary structure of the r(CUUCGG) tetraloop" @default.
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• W2144861653 doi "https://doi.org/10.1093/nar/24.20.4015" @default.
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