Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144877467> ?p ?o ?g. }
- W2144877467 endingPage "2358" @default.
- W2144877467 startingPage "2349" @default.
- W2144877467 abstract "Porphyromonas gingivalis is an oral/systemic pathogen implicated in chronic conditions, although the mechanism(s) whereby it resists immune defenses and persists in the host is poorly understood. The virulence of this pathogen partially depends upon expression of fimbriae comprising polymerized fimbrillin (FimA) associated with quantitatively minor proteins (FimCDE). In this study, we show that isogenic mutants lacking FimCDE are dramatically less persistent and virulent in a mouse periodontitis model and express shorter fimbriae than the wild type. Strikingly, native fimbriae allowed P. gingivalis to exploit the TLR2/complement receptor 3 pathway for intracellular entry, inhibition of IL-12p70, and persistence in macrophages. This virulence mechanism also required FimCDE; indeed, mutant strains exhibited significantly reduced ability to inhibit IL-12p70, invade, and persist intracellularly, attributable to failure to interact with complement receptor 3, although not with TLR2. These results highlight a hitherto unknown mechanism of immune evasion by P. gingivalis that is surprisingly dependent upon minor constituents of its fimbriae, and support the concept that pathogens evolved to manipulate innate immunity for promoting adaptive fitness and thus their capacity to cause disease." @default.
- W2144877467 created "2016-06-24" @default.
- W2144877467 creator A5009202130 @default.
- W2144877467 creator A5009532166 @default.
- W2144877467 creator A5015102287 @default.
- W2144877467 creator A5043136018 @default.
- W2144877467 creator A5071046874 @default.
- W2144877467 creator A5084031628 @default.
- W2144877467 creator A5084351823 @default.
- W2144877467 creator A5085761568 @default.
- W2144877467 date "2007-08-03" @default.
- W2144877467 modified "2023-10-16" @default.
- W2144877467 title "Fimbrial Proteins of<i>Porphyromonas gingivalis</i>Mediate In Vivo Virulence and Exploit TLR2 and Complement Receptor 3 to Persist in Macrophages" @default.
- W2144877467 cites W1500570195 @default.
- W2144877467 cites W1527241561 @default.
- W2144877467 cites W1926929786 @default.
- W2144877467 cites W1970068894 @default.
- W2144877467 cites W1971135092 @default.
- W2144877467 cites W1987756723 @default.
- W2144877467 cites W2006446093 @default.
- W2144877467 cites W2009219530 @default.
- W2144877467 cites W2013039381 @default.
- W2144877467 cites W2014259119 @default.
- W2144877467 cites W2016622249 @default.
- W2144877467 cites W2026735248 @default.
- W2144877467 cites W2032718936 @default.
- W2144877467 cites W2038713847 @default.
- W2144877467 cites W2042111787 @default.
- W2144877467 cites W2044097621 @default.
- W2144877467 cites W2046641769 @default.
- W2144877467 cites W2056573320 @default.
- W2144877467 cites W2061678562 @default.
- W2144877467 cites W2063749886 @default.
- W2144877467 cites W2071899271 @default.
- W2144877467 cites W2088618181 @default.
- W2144877467 cites W2096878710 @default.
- W2144877467 cites W2097181782 @default.
- W2144877467 cites W2108985104 @default.
- W2144877467 cites W2111104826 @default.
- W2144877467 cites W2112738510 @default.
- W2144877467 cites W2117845905 @default.
- W2144877467 cites W2122456003 @default.
- W2144877467 cites W2124371255 @default.
- W2144877467 cites W2129443960 @default.
- W2144877467 cites W2132019676 @default.
- W2144877467 cites W2133664523 @default.
- W2144877467 cites W2145638464 @default.
- W2144877467 cites W2151805768 @default.
- W2144877467 cites W2155099281 @default.
- W2144877467 cites W2157107389 @default.
- W2144877467 cites W2158754447 @default.
- W2144877467 cites W2159981485 @default.
- W2144877467 cites W2165919222 @default.
- W2144877467 cites W2167491944 @default.
- W2144877467 cites W2169804428 @default.
- W2144877467 cites W2170863757 @default.
- W2144877467 cites W4210956735 @default.
- W2144877467 doi "https://doi.org/10.4049/jimmunol.179.4.2349" @default.
- W2144877467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17675496" @default.
- W2144877467 hasPublicationYear "2007" @default.
- W2144877467 type Work @default.
- W2144877467 sameAs 2144877467 @default.
- W2144877467 citedByCount "168" @default.
- W2144877467 countsByYear W21448774672012 @default.
- W2144877467 countsByYear W21448774672013 @default.
- W2144877467 countsByYear W21448774672014 @default.
- W2144877467 countsByYear W21448774672015 @default.
- W2144877467 countsByYear W21448774672016 @default.
- W2144877467 countsByYear W21448774672017 @default.
- W2144877467 countsByYear W21448774672018 @default.
- W2144877467 countsByYear W21448774672019 @default.
- W2144877467 countsByYear W21448774672020 @default.
- W2144877467 countsByYear W21448774672021 @default.
- W2144877467 countsByYear W21448774672022 @default.
- W2144877467 countsByYear W21448774672023 @default.
- W2144877467 crossrefType "journal-article" @default.
- W2144877467 hasAuthorship W2144877467A5009202130 @default.
- W2144877467 hasAuthorship W2144877467A5009532166 @default.
- W2144877467 hasAuthorship W2144877467A5015102287 @default.
- W2144877467 hasAuthorship W2144877467A5043136018 @default.
- W2144877467 hasAuthorship W2144877467A5071046874 @default.
- W2144877467 hasAuthorship W2144877467A5084031628 @default.
- W2144877467 hasAuthorship W2144877467A5084351823 @default.
- W2144877467 hasAuthorship W2144877467A5085761568 @default.
- W2144877467 hasBestOaLocation W21448774671 @default.
- W2144877467 hasConcept C104317684 @default.
- W2144877467 hasConcept C136449434 @default.
- W2144877467 hasConcept C170493617 @default.
- W2144877467 hasConcept C203014093 @default.
- W2144877467 hasConcept C2776460866 @default.
- W2144877467 hasConcept C2776709828 @default.
- W2144877467 hasConcept C2780014169 @default.
- W2144877467 hasConcept C2780183776 @default.
- W2144877467 hasConcept C2781090273 @default.
- W2144877467 hasConcept C2781236682 @default.
- W2144877467 hasConcept C39103817 @default.
- W2144877467 hasConcept C523546767 @default.
- W2144877467 hasConcept C54355233 @default.