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• W2144879440 abstract "We previously reported that lysoplasmenylcholine (LPlasC) altered the action potential (AP) and induced afterdepolarizations in rabbit ventricular myocytes. In this study, we investigated how LPlasC alters excitation-contraction coupling using edge-motion detection, fura-PE3 fluorescent indicator, and perforated and whole cell patch-clamp techniques. LPlasC increased contraction, myofilament Ca 2+ sensitivity, systolic and diastolic free Ca 2+ levels, and the magnitude of Ca 2+ transients concomitant with increases in the maximum rates of shortening and relaxation of contraction and the rising and declining phases of Ca 2+ transients. In some cells, LPlasC induced arrhythmias in a pattern consistent with early and delayed aftercontractions. LPlasC also augmented the caffeine-induced Ca 2+ transient with a reduction in the decay rate. Furthermore, LPlasC enhanced L-type Ca 2+ channel current ( I Ca,L ) and outward currents. LPlasC-induced alterations in contraction and I Ca,L were paralleled by its effect on the AP. Thus these results suggest that LPlasC elicits distinct, potent positive inotropic, lusitropic, and arrhythmogenic effects, resulting from increases in Ca 2+ influx, Ca 2+ sensitivity, sarcoplasmic reticular (SR) Ca 2+ release and uptake, SR Ca 2+ content, and probably reduction in sarcolemmal Na + /Ca 2+ exchange." @default.
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• W2144879440 date "2003-04-01" @default.
• W2144879440 modified "2023-10-17" @default.
• W2144879440 title "Alterations in Ca²⁺cycling by lysoplasmenylcholine in adult rabbit ventricular myocytes" @default.
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• W2144879440 doi "https://doi.org/10.1152/ajpcell.00465.2002" @default.
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