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- W2144893180 endingPage "314" @default.
- W2144893180 startingPage "285" @default.
- W2144893180 abstract "Metals are commonly found as natural constituents of proteins. Since many such metals can interact specifically with their corresponding unfolded proteins in vitro , cofactor-binding prior to polypeptide folding may be a biological path to active metalloproteins. By interacting with the unfolded polypeptide, the metal may create local structure that initiates and directs the polypeptide-folding process. Here, we review recent literature that addresses the involvement of metals in protein-folding reactions in vitro . To date, the best characterized systems are simple one such as blue-copper proteins, heme-binding proteins, iron-sulfur-cluster proteins and synthetic metallopeptides. Taken together, the available data demonstrates that metals can play diverse roles: it is clear that many cofactors bind before polypeptide folding and influence the reaction; yet, some do not bind until a well-structured active site is formed. The significance of characterizing the effects of metals on protein conformational changes is underscored by the many human diseases that are directly linked to anomalous protein-metal interactions." @default.
- W2144893180 created "2016-06-24" @default.
- W2144893180 creator A5051928700 @default.
- W2144893180 creator A5063954863 @default.
- W2144893180 creator A5089483531 @default.
- W2144893180 date "2004-11-01" @default.
- W2144893180 modified "2023-10-01" @default.
- W2144893180 title "Role of cofactors in metalloprotein folding" @default.
- W2144893180 cites W1484887786 @default.
- W2144893180 cites W1489286950 @default.
- W2144893180 cites W1490423318 @default.
- W2144893180 cites W1505478715 @default.
- W2144893180 cites W1510071974 @default.
- W2144893180 cites W1533678398 @default.
- W2144893180 cites W1551903256 @default.
- W2144893180 cites W1552236928 @default.
- W2144893180 cites W1573631659 @default.
- W2144893180 cites W1578537067 @default.
- W2144893180 cites W1581835703 @default.
- W2144893180 cites W1585758755 @default.
- W2144893180 cites W1603204990 @default.
- W2144893180 cites W1824346003 @default.
- W2144893180 cites W1849447163 @default.
- W2144893180 cites W1868379549 @default.
- W2144893180 cites W193624147 @default.
- W2144893180 cites W1963874808 @default.
- W2144893180 cites W1966524358 @default.
- W2144893180 cites W1967305892 @default.
- W2144893180 cites W1968291593 @default.
- W2144893180 cites W1968640720 @default.
- W2144893180 cites W1968673134 @default.
- W2144893180 cites W1968888329 @default.
- W2144893180 cites W1969076017 @default.
- W2144893180 cites W1969531857 @default.
- W2144893180 cites W1969760979 @default.
- W2144893180 cites W1972324784 @default.
- W2144893180 cites W1973106905 @default.
- W2144893180 cites W1973862763 @default.
- W2144893180 cites W1975764245 @default.
- W2144893180 cites W1977470145 @default.
- W2144893180 cites W1978373405 @default.
- W2144893180 cites W1979043241 @default.
- W2144893180 cites W1979707070 @default.
- W2144893180 cites W1983974198 @default.
- W2144893180 cites W1986438501 @default.
- W2144893180 cites W1986462477 @default.
- W2144893180 cites W1986566642 @default.
- W2144893180 cites W1988431686 @default.
- W2144893180 cites W1988624456 @default.
- W2144893180 cites W1989297730 @default.
- W2144893180 cites W1992535253 @default.
- W2144893180 cites W1992661805 @default.
- W2144893180 cites W1997805535 @default.
- W2144893180 cites W1998034059 @default.
- W2144893180 cites W1998847407 @default.
- W2144893180 cites W2000959843 @default.
- W2144893180 cites W2001035885 @default.
- W2144893180 cites W2002600593 @default.
- W2144893180 cites W2003890109 @default.
- W2144893180 cites W2005587040 @default.
- W2144893180 cites W2006525411 @default.
- W2144893180 cites W2009833553 @default.
- W2144893180 cites W2011314862 @default.
- W2144893180 cites W2012110080 @default.
- W2144893180 cites W2012370493 @default.
- W2144893180 cites W2014486412 @default.
- W2144893180 cites W2016781886 @default.
- W2144893180 cites W2017785367 @default.
- W2144893180 cites W2023015137 @default.
- W2144893180 cites W2024443281 @default.
- W2144893180 cites W2024554086 @default.
- W2144893180 cites W2025603410 @default.
- W2144893180 cites W2027465657 @default.
- W2144893180 cites W2029554137 @default.
- W2144893180 cites W2029627760 @default.
- W2144893180 cites W2030491877 @default.
- W2144893180 cites W2031006390 @default.
- W2144893180 cites W2031565986 @default.
- W2144893180 cites W2032881767 @default.
- W2144893180 cites W2035594105 @default.
- W2144893180 cites W2035998327 @default.
- W2144893180 cites W2037346057 @default.
- W2144893180 cites W2038978336 @default.
- W2144893180 cites W2040362675 @default.
- W2144893180 cites W2041446399 @default.
- W2144893180 cites W2041540030 @default.
- W2144893180 cites W2043821193 @default.
- W2144893180 cites W2045246676 @default.
- W2144893180 cites W2045288235 @default.
- W2144893180 cites W2046760571 @default.
- W2144893180 cites W2046907059 @default.
- W2144893180 cites W2048374209 @default.
- W2144893180 cites W2050029569 @default.
- W2144893180 cites W2052559661 @default.
- W2144893180 cites W2053595538 @default.
- W2144893180 cites W2054153889 @default.
- W2144893180 cites W2054753086 @default.
- W2144893180 cites W2056722520 @default.