Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144911700> ?p ?o ?g. }
- W2144911700 endingPage "275" @default.
- W2144911700 startingPage "260" @default.
- W2144911700 abstract "Our work characterizes the effects of opiate (morphine) dependence on auditory brainstem and visual evoked responses in a rhesus macaque model of neuro-AIDS utilizing a chronic continuous drug delivery paradigm. The goal of this study was to clarify whether morphine is protective, or if it exacerbates simian immunodeficiency virus (SIV)-related systemic and neurological disease. Our model employs a macrophage tropic CD4/CCR5 coreceptor virus, SIVmac239 (R71/E17), which crosses the blood-brain barrier shortly after inoculation and closely mimics the natural disease course of human immunodeficiency virus infection. The cohort was divided into three groups: morphine only, SIV only, and SIV + morphine. Evoked potential (EP) abnormalities in subclinically infected macaques were evident as early as 8 weeks postinoculation. Prolongations in EP latencies were observed in SIV-infected macaques across all modalities. Animals with the highest cerebrospinal fluid viral loads and clinical disease showed more abnormalities than those with subclinical disease, confirming our previous work (Raymond et al., J Neurovirol 4:512–520, 1998; J Neurovirol 5:217–231, 1999; AIDS Res Hum Retroviruses 16:1163–1173, 2000). Although some differences were observed in auditory and visual evoked potentials in morphine-treated compared to morphine-untreated SIV-infected animals, the effects were relatively small and not consistent across evoked potential type. However, morphine-treated animals with subclinical disease had a clear tendency toward higher virus loads in peripheral and central nervous system tissues (Marcario et al., J Neuroimmune Pharmacol 3:12–25, 2008) suggesting that if had been possible to follow all animals to end-stage disease, a clearer pattern of evoked potential abnormality might have emerged." @default.
- W2144911700 created "2016-06-24" @default.
- W2144911700 creator A5010203239 @default.
- W2144911700 creator A5014145005 @default.
- W2144911700 creator A5029949592 @default.
- W2144911700 creator A5037052048 @default.
- W2144911700 creator A5044969361 @default.
- W2144911700 creator A5045297888 @default.
- W2144911700 creator A5048405297 @default.
- W2144911700 creator A5050558681 @default.
- W2144911700 creator A5057647303 @default.
- W2144911700 creator A5077816419 @default.
- W2144911700 date "2009-03-13" @default.
- W2144911700 modified "2023-09-24" @default.
- W2144911700 title "Rhesus Macaque Model of Chronic Opiate Dependence and Neuro-AIDS: Longitudinal Assessment of Auditory Brainstem Responses and Visual Evoked Potentials" @default.
- W2144911700 cites W1515616973 @default.
- W2144911700 cites W1901309030 @default.
- W2144911700 cites W1966998578 @default.
- W2144911700 cites W1967908924 @default.
- W2144911700 cites W1967967289 @default.
- W2144911700 cites W1969653523 @default.
- W2144911700 cites W1970671202 @default.
- W2144911700 cites W1973385259 @default.
- W2144911700 cites W1974440945 @default.
- W2144911700 cites W1978346461 @default.
- W2144911700 cites W1981440980 @default.
- W2144911700 cites W1981568274 @default.
- W2144911700 cites W1981644527 @default.
- W2144911700 cites W1986648058 @default.
- W2144911700 cites W1991785343 @default.
- W2144911700 cites W1992620115 @default.
- W2144911700 cites W1995031377 @default.
- W2144911700 cites W1996183144 @default.
- W2144911700 cites W1997389594 @default.
- W2144911700 cites W1999478240 @default.
- W2144911700 cites W2000114895 @default.
- W2144911700 cites W2000388934 @default.
- W2144911700 cites W2002254372 @default.
- W2144911700 cites W2003356209 @default.
- W2144911700 cites W2003538644 @default.
- W2144911700 cites W2005807968 @default.
- W2144911700 cites W2008178649 @default.
- W2144911700 cites W2008662192 @default.
- W2144911700 cites W2008994596 @default.
- W2144911700 cites W2009915570 @default.
- W2144911700 cites W2012547110 @default.
- W2144911700 cites W2013285413 @default.
- W2144911700 cites W2014651440 @default.
- W2144911700 cites W2017571495 @default.
- W2144911700 cites W2019869740 @default.
- W2144911700 cites W2028493550 @default.
- W2144911700 cites W2029448679 @default.
- W2144911700 cites W2031602816 @default.
- W2144911700 cites W2033078023 @default.
- W2144911700 cites W2037732145 @default.
- W2144911700 cites W2037871804 @default.
- W2144911700 cites W2039470219 @default.
- W2144911700 cites W2042971904 @default.
- W2144911700 cites W2046157554 @default.
- W2144911700 cites W2047890674 @default.
- W2144911700 cites W2053631570 @default.
- W2144911700 cites W2054603112 @default.
- W2144911700 cites W2058444932 @default.
- W2144911700 cites W2059865376 @default.
- W2144911700 cites W2059995904 @default.
- W2144911700 cites W2061060715 @default.
- W2144911700 cites W2061839353 @default.
- W2144911700 cites W2062205849 @default.
- W2144911700 cites W2068566665 @default.
- W2144911700 cites W2069506578 @default.
- W2144911700 cites W2069663390 @default.
- W2144911700 cites W2070119077 @default.
- W2144911700 cites W2073281529 @default.
- W2144911700 cites W2076210505 @default.
- W2144911700 cites W2076700278 @default.
- W2144911700 cites W2081173744 @default.
- W2144911700 cites W2081461296 @default.
- W2144911700 cites W2082048768 @default.
- W2144911700 cites W2083544690 @default.
- W2144911700 cites W2090532515 @default.
- W2144911700 cites W2091771288 @default.
- W2144911700 cites W2092254496 @default.
- W2144911700 cites W2094815999 @default.
- W2144911700 cites W2106513047 @default.
- W2144911700 cites W2106779858 @default.
- W2144911700 cites W2112517802 @default.
- W2144911700 cites W2113060649 @default.
- W2144911700 cites W2116097076 @default.
- W2144911700 cites W2124769253 @default.
- W2144911700 cites W2124913197 @default.
- W2144911700 cites W2125202557 @default.
- W2144911700 cites W2134540925 @default.
- W2144911700 cites W2137807121 @default.
- W2144911700 cites W2140150768 @default.
- W2144911700 cites W2151300975 @default.
- W2144911700 cites W2159089689 @default.
- W2144911700 cites W2159990490 @default.
- W2144911700 cites W2164317596 @default.