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- W2144920267 abstract "Hypoplastic left heart syndrome (HLHS) inevitably results in death within a few weeks of birth, and the surgical treatment for this condition involves three complex surgeries that are associated with a high mortality and cost (1). The mortality rates for the first-stage procedure range from 25-80% at medical centers worldwide. Moreover, many children (possibly as many as 50%, according to hospitals where accurate records are kept) with this disease are not referred for surgery and progress to death within days or weeks (2-4). The two conventional techniques that are used for the Norwood procedure (the first-stage surgical correction) involve the construction of a systemic pulmonary shunt. This procedure performed using the Blalock-Taussig technique leads to a diastolic systemic pulmonary flow that mimics systemic valve insufficiency. When performed using the Sano modification technique, the Norwood procedure involves building a tube between the systemic ventricle and the pulmonary artery; this technique avoids the diastolic systemic pulmonary flow but allows the blood in the lungs to reflux to the single ventricle, which increases the volume overload. This overload associated with ventriculotomy may lead to dysfunction of the ventricle and arrhythmia. Moreover, both techniques necessitate the use of an artificial tube and carry a risk for thrombosis or stenosis (5-9). Additionally, fabrication of the neo-aorta is a laborious technique that requires the extended use of extracorporeal circulation (ECC).Hybrid approaches involving the maintenance of the patent ductus arteriosus with the implantation of a stent (10,11) or the prolonged administration of prostaglandin E1 (12) associated with the banding of the pulmonary branches simplifies the surgical approach but have yielded unsatisfactory results (13,14)." @default.
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- W2144920267 date "2012-05-15" @default.
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- W2144920267 title "A new technique for the correction of hypoplastic left heart syndrome" @default.
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- W2144920267 doi "https://doi.org/10.6061/clinics/2012(05)20" @default.
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