Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144921455> ?p ?o ?g. }
- W2144921455 endingPage "174" @default.
- W2144921455 startingPage "165" @default.
- W2144921455 abstract "The α1,6 fucosyltransferase (α1,6 FucT) catalyzes the transfer of a fucose from GDP-fucose to the innermost GlcNAc residue of N-linked glycans via an α1,6 linkage. α1,6 FucT was overexpressed in transgenic mice under the control of a combined cytomegalovirus and chicken β-actin promoter. Histologically numerous small vacuoles, in which lipid droplets had accumulated, were observed in hepatocytes and proximal renal tubular cells. Electron microscopic studies showed that the lipid droplets were membrane-bound and apparently localized within the lysosomes. Cholesterol esters and triglycerides were significantly increased in liver and kidney of the transgenic mice. Liver lysosomal acid lipase (LAL) activity was significantly lower in the transgenic mice compared to the wild mice, whereas LAL protein level, which was detected immunochemically, was increased, indicating that the specific activity of LAL was much lower in the transgenic mice. In all of the transgenic and nontransgenic mice examined, the activity of liver LAL was negatively correlated with the level of α1,6 FucT activity. As evidenced by lectin and immunoblot analysis, LAL was found to be more fucosylated in the transgenic mice, suggesting that the aberrant fucosylation of LAL causes an accumulation of inactive LAL in the lysosomes. Such an accumulation of inactive LAL could be a likely cause for a steatosis in the lysosomes of the liver and kidney in the case of the α1,6 FucT transgenic mice." @default.
- W2144921455 created "2016-06-24" @default.
- W2144921455 creator A5000432967 @default.
- W2144921455 creator A5002045785 @default.
- W2144921455 creator A5002124141 @default.
- W2144921455 creator A5015048316 @default.
- W2144921455 creator A5017269198 @default.
- W2144921455 creator A5017989247 @default.
- W2144921455 creator A5028849312 @default.
- W2144921455 creator A5042864917 @default.
- W2144921455 creator A5044178319 @default.
- W2144921455 creator A5050137901 @default.
- W2144921455 creator A5078795928 @default.
- W2144921455 creator A5080369708 @default.
- W2144921455 creator A5086129270 @default.
- W2144921455 creator A5089216722 @default.
- W2144921455 creator A5090272663 @default.
- W2144921455 creator A5059930538 @default.
- W2144921455 date "2001-02-01" @default.
- W2144921455 modified "2023-10-03" @default.
- W2144921455 title "Ectopic expression of 1,6 fucosyltransferase in mice causes steatosis in the liver and kidney accompanied by a modification of lysosomal acid lipase" @default.
- W2144921455 cites W111279876 @default.
- W2144921455 cites W1503337358 @default.
- W2144921455 cites W1526263644 @default.
- W2144921455 cites W1873706815 @default.
- W2144921455 cites W1901525248 @default.
- W2144921455 cites W1932732423 @default.
- W2144921455 cites W1963953615 @default.
- W2144921455 cites W1973466034 @default.
- W2144921455 cites W1977606211 @default.
- W2144921455 cites W1979815475 @default.
- W2144921455 cites W1981545608 @default.
- W2144921455 cites W1982957566 @default.
- W2144921455 cites W1983935237 @default.
- W2144921455 cites W1987581820 @default.
- W2144921455 cites W1992864925 @default.
- W2144921455 cites W1999057258 @default.
- W2144921455 cites W2003661489 @default.
- W2144921455 cites W2003809907 @default.
- W2144921455 cites W2007647348 @default.
- W2144921455 cites W2018172904 @default.
- W2144921455 cites W2021714714 @default.
- W2144921455 cites W2023587709 @default.
- W2144921455 cites W2026582922 @default.
- W2144921455 cites W2031721787 @default.
- W2144921455 cites W2041547641 @default.
- W2144921455 cites W2042381594 @default.
- W2144921455 cites W2046274848 @default.
- W2144921455 cites W2047706169 @default.
- W2144921455 cites W2061100651 @default.
- W2144921455 cites W2062440014 @default.
- W2144921455 cites W2072608022 @default.
- W2144921455 cites W2076445790 @default.
- W2144921455 cites W2077975666 @default.
- W2144921455 cites W2086100286 @default.
- W2144921455 cites W2092278506 @default.
- W2144921455 cites W2100842605 @default.
- W2144921455 cites W2123116985 @default.
- W2144921455 cites W2147029772 @default.
- W2144921455 cites W2161375000 @default.
- W2144921455 cites W2306545604 @default.
- W2144921455 cites W2403987486 @default.
- W2144921455 cites W2411294738 @default.
- W2144921455 cites W253205119 @default.
- W2144921455 cites W4245662805 @default.
- W2144921455 cites W4245881395 @default.
- W2144921455 cites W4249125370 @default.
- W2144921455 cites W62982708 @default.
- W2144921455 doi "https://doi.org/10.1093/glycob/11.2.165" @default.
- W2144921455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11287403" @default.
- W2144921455 hasPublicationYear "2001" @default.
- W2144921455 type Work @default.
- W2144921455 sameAs 2144921455 @default.
- W2144921455 citedByCount "29" @default.
- W2144921455 countsByYear W21449214552012 @default.
- W2144921455 countsByYear W21449214552014 @default.
- W2144921455 countsByYear W21449214552015 @default.
- W2144921455 countsByYear W21449214552016 @default.
- W2144921455 countsByYear W21449214552018 @default.
- W2144921455 countsByYear W21449214552019 @default.
- W2144921455 countsByYear W21449214552020 @default.
- W2144921455 countsByYear W21449214552021 @default.
- W2144921455 crossrefType "journal-article" @default.
- W2144921455 hasAuthorship W2144921455A5000432967 @default.
- W2144921455 hasAuthorship W2144921455A5002045785 @default.
- W2144921455 hasAuthorship W2144921455A5002124141 @default.
- W2144921455 hasAuthorship W2144921455A5015048316 @default.
- W2144921455 hasAuthorship W2144921455A5017269198 @default.
- W2144921455 hasAuthorship W2144921455A5017989247 @default.
- W2144921455 hasAuthorship W2144921455A5028849312 @default.
- W2144921455 hasAuthorship W2144921455A5042864917 @default.
- W2144921455 hasAuthorship W2144921455A5044178319 @default.
- W2144921455 hasAuthorship W2144921455A5050137901 @default.
- W2144921455 hasAuthorship W2144921455A5059930538 @default.
- W2144921455 hasAuthorship W2144921455A5078795928 @default.
- W2144921455 hasAuthorship W2144921455A5080369708 @default.
- W2144921455 hasAuthorship W2144921455A5086129270 @default.
- W2144921455 hasAuthorship W2144921455A5089216722 @default.