FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144938963> ?p ?o ?g. }

• W2144938963 endingPage "559" @default.
• W2144938963 startingPage "550" @default.
• W2144938963 abstract "Resistant hypertension defined as requiring 3 or more complementary antihypertensive drugs at maximally tolerated doses accounts for approximately 3% to 4% of all cases of hypertension. Its increased incidence over the past decade is related to the increase in obesity in the Western world. There are a number of dietary factors that affect sympathetic tone including sodium intake apart from increased body mass. This article discusses the mechanisms of sympathetic stimulation and activation in the context of animal models and human studies. In addition, there is a review of clinical trials with and without device therapy that summarizes the clinical findings. Effective management should be based on pathophysiologic principles and a focus on blood pressure reduction to levels well below 150/90 mm Hg because outcome trial evidence and Food and Drug Administration guidance supports this construct. The key to success of device-based therapy depends on identifying the cohort with true resistant hypertension that can benefit from therapies that are adjuncts to pharmacotherapy. Physicians need to concentrate on educating the patient on lifestyle modifications and themselves on use of proper combinations of antihypertensive medications. If this approach fails to result in a safe level of blood pressure then the patient should be referred to a board-certified clinical hypertension specialist. Resistant hypertension defined as requiring 3 or more complementary antihypertensive drugs at maximally tolerated doses accounts for approximately 3% to 4% of all cases of hypertension. Its increased incidence over the past decade is related to the increase in obesity in the Western world. There are a number of dietary factors that affect sympathetic tone including sodium intake apart from increased body mass. This article discusses the mechanisms of sympathetic stimulation and activation in the context of animal models and human studies. In addition, there is a review of clinical trials with and without device therapy that summarizes the clinical findings. Effective management should be based on pathophysiologic principles and a focus on blood pressure reduction to levels well below 150/90 mm Hg because outcome trial evidence and Food and Drug Administration guidance supports this construct. The key to success of device-based therapy depends on identifying the cohort with true resistant hypertension that can benefit from therapies that are adjuncts to pharmacotherapy. Physicians need to concentrate on educating the patient on lifestyle modifications and themselves on use of proper combinations of antihypertensive medications. If this approach fails to result in a safe level of blood pressure then the patient should be referred to a board-certified clinical hypertension specialist." @default.
• W2144938963 created "2016-06-24" @default.
• W2144938963 creator A5012514694 @default.
• W2144938963 creator A5064094952 @default.
• W2144938963 date "2014-09-01" @default.
• W2144938963 modified "2023-09-23" @default.
• W2144938963 title "Sympathetic Activation in Resistant Hypertension: Theory and Therapy" @default.
• W2144938963 cites W1481523571 @default.
• W2144938963 cites W1583834060 @default.
• W2144938963 cites W167701172 @default.
• W2144938963 cites W1819620602 @default.
• W2144938963 cites W1966027288 @default.
• W2144938963 cites W1966296375 @default.
• W2144938963 cites W1967247651 @default.
• W2144938963 cites W1967477492 @default.
• W2144938963 cites W1969506301 @default.
• W2144938963 cites W1971919493 @default.
• W2144938963 cites W1978585499 @default.
• W2144938963 cites W1980308464 @default.
• W2144938963 cites W1981364522 @default.
• W2144938963 cites W1983398430 @default.
• W2144938963 cites W1988388756 @default.
• W2144938963 cites W1993599355 @default.
• W2144938963 cites W1995194227 @default.
• W2144938963 cites W2014217182 @default.
• W2144938963 cites W2021305708 @default.
• W2144938963 cites W2022522361 @default.
• W2144938963 cites W2027280490 @default.
• W2144938963 cites W2027795929 @default.
• W2144938963 cites W2033568948 @default.
• W2144938963 cites W2048790186 @default.
• W2144938963 cites W2049397775 @default.
• W2144938963 cites W2051001077 @default.
• W2144938963 cites W2051768636 @default.
• W2144938963 cites W2055014315 @default.
• W2144938963 cites W2056367362 @default.
• W2144938963 cites W2062562517 @default.
• W2144938963 cites W2064532153 @default.
• W2144938963 cites W2065689558 @default.
• W2144938963 cites W2070854138 @default.
• W2144938963 cites W2070878188 @default.
• W2144938963 cites W2071080517 @default.
• W2144938963 cites W2073002995 @default.
• W2144938963 cites W2076897983 @default.
• W2144938963 cites W2077179567 @default.
• W2144938963 cites W2093198429 @default.
• W2144938963 cites W2093272398 @default.
• W2144938963 cites W2095768373 @default.
• W2144938963 cites W2096137930 @default.
• W2144938963 cites W2100409734 @default.
• W2144938963 cites W2101204313 @default.
• W2144938963 cites W2101394903 @default.
• W2144938963 cites W2102620697 @default.
• W2144938963 cites W2103015566 @default.
• W2144938963 cites W2109187758 @default.
• W2144938963 cites W2114127328 @default.
• W2144938963 cites W2115461708 @default.
• W2144938963 cites W2115856029 @default.
• W2144938963 cites W2118344567 @default.
• W2144938963 cites W2126125759 @default.
• W2144938963 cites W2130206139 @default.
• W2144938963 cites W2140449653 @default.
• W2144938963 cites W2142772495 @default.
• W2144938963 cites W2142937102 @default.
• W2144938963 cites W2146303375 @default.
• W2144938963 cites W2148222582 @default.
• W2144938963 cites W2148313399 @default.
• W2144938963 cites W2149207625 @default.
• W2144938963 cites W2150333966 @default.
• W2144938963 cites W2152798629 @default.
• W2144938963 cites W21544270 @default.
• W2144938963 cites W2156121263 @default.
• W2144938963 cites W2158050604 @default.
• W2144938963 cites W2163519610 @default.
• W2144938963 cites W2166806488 @default.
• W2144938963 cites W2170880252 @default.
• W2144938963 cites W2171667495 @default.
• W2144938963 cites W2171818587 @default.
• W2144938963 cites W2289116881 @default.
• W2144938963 cites W2321711947 @default.
• W2144938963 cites W2329025098 @default.
• W2144938963 cites W2435196677 @default.
• W2144938963 cites W2477567742 @default.
• W2144938963 cites W3144014357 @default.
• W2144938963 cites W4205373146 @default.
• W2144938963 cites W4236224862 @default.
• W2144938963 cites W4249344264 @default.
• W2144938963 doi "https://doi.org/10.1016/j.semnephrol.2014.08.009" @default.
• W2144938963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25416664" @default.
• W2144938963 hasPublicationYear "2014" @default.
• W2144938963 type Work @default.
• W2144938963 sameAs 2144938963 @default.
• W2144938963 citedByCount "11" @default.
• W2144938963 countsByYear W21449389632015 @default.
• W2144938963 countsByYear W21449389632017 @default.
• W2144938963 countsByYear W21449389632018 @default.
• W2144938963 countsByYear W21449389632019 @default.
• W2144938963 countsByYear W21449389632020 @default.

• next