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• W2144961715 abstract "Abstract N‐Dealkylation methods are well described for organic chemistry and the reaction is known in nature and drug metabolism; however, to our knowledge, enantioselective N‐dealkylation has not been yet reported. In this study, exclusively the ( S )‐enantiomers of racemic N ‐ethyl tertiary amines (1‐benzyl‐ N ‐ethyl‐1,2,3,4‐tetrahydroisoquinolines) were dealkylated to give the corresponding secondary ( S )‐amines in an enantioselective fashion at the expense of molecular oxygen. The reaction is catalyzed by the berberine bridge enzyme, which is known for CC bond formation. The dealkylation was demonstrated on a 100 mg scale and gave optically pure dealkylated products ( ee >99 %)." @default.
• W2144961715 created "2016-06-24" @default.
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• W2144961715 date "2015-10-21" @default.
• W2144961715 modified "2023-10-18" @default.
• W2144961715 title "Enantioselective Oxidative Aerobic Dealkylation of<i>N</i>-Ethyl Benzylisoquinolines by Employing the Berberine Bridge Enzyme" @default.
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• W2144961715 doi "https://doi.org/10.1002/anie.201507970" @default.
• W2144961715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26487450" @default.
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