Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144966808> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2144966808 endingPage "1001" @default.
- W2144966808 startingPage "999" @default.
- W2144966808 abstract "Gammaretroviral vectors are an efficient means to effect gene therapy. However, genotoxicity from insertion at nonrandom sites can confer a competitive advantage to transduced cells, resulting in clonal proliferation or neoplasia. Six pig-tailed macaques (Macaca nemestrina) underwent total body irradiation and reconstitution with autologous stem cells genetically modified by a gammaretroviral vector overexpressing HOXB4. Two animals were euthanized owing to irradiation- or transplantation-associated toxicity, whereas the other 4 had successful reconstitution. Of the 4 macaques with successful reconstitution, 1 has no long-term follow-up information; 1 was euthanized owing to infection with simian varicella virus infection 18 months post-total body irradiation; and the 2 others are described herein as case Nos. 1 and 2. After being stable for 3 years, case No. 1 developed pancytopenia and petechiation, and after 2 years of stability case No. 2 developed anemia and thrombocytopenia. Despite therapy, the animals deteriorated and were euthanized. Gross findings included emaciation; case No. 1 also had hemorrhage, peritonitis, and cholecystitis. Histologically, bone marrow was hypercellular with predominately blast cells of all hematopoietic lineages, though with myeloid predominance, and with maturation arrest and blast cell dysplasia (myelodysplasia). Myelodysplasia was likely from a combination of insertional mutagenesis by the retroviral vector and overexpression of HOXB4. Consequences of myelodysplasia included the blood dyscrasias and, in case No. 1, hemorrhage, bacterial cholecystitis, hepatitis, and peritonitis." @default.
- W2144966808 created "2016-06-24" @default.
- W2144966808 creator A5040175276 @default.
- W2144966808 creator A5060509285 @default.
- W2144966808 creator A5060993908 @default.
- W2144966808 creator A5061050137 @default.
- W2144966808 creator A5067294494 @default.
- W2144966808 creator A5089267885 @default.
- W2144966808 date "2010-09-24" @default.
- W2144966808 modified "2023-10-08" @default.
- W2144966808 title "Myelodysplasia in 2 Pig-Tailed Macaques (<i>Macaca nemestrina</i>) Associated With Retroviral Vector–Mediated Insertional Mutagenesis and Overexpression of <i>HOXB4</i>" @default.
- W2144966808 cites W1981481637 @default.
- W2144966808 cites W2054842943 @default.
- W2144966808 cites W2057879405 @default.
- W2144966808 cites W2102660504 @default.
- W2144966808 cites W2107046588 @default.
- W2144966808 cites W2118765054 @default.
- W2144966808 cites W2119324304 @default.
- W2144966808 cites W2137440275 @default.
- W2144966808 doi "https://doi.org/10.1177/0300985810382673" @default.
- W2144966808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3162117" @default.
- W2144966808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20870955" @default.
- W2144966808 hasPublicationYear "2010" @default.
- W2144966808 type Work @default.
- W2144966808 sameAs 2144966808 @default.
- W2144966808 citedByCount "5" @default.
- W2144966808 countsByYear W21449668082013 @default.
- W2144966808 countsByYear W21449668082014 @default.
- W2144966808 countsByYear W21449668082022 @default.
- W2144966808 crossrefType "journal-article" @default.
- W2144966808 hasAuthorship W2144966808A5040175276 @default.
- W2144966808 hasAuthorship W2144966808A5060509285 @default.
- W2144966808 hasAuthorship W2144966808A5060993908 @default.
- W2144966808 hasAuthorship W2144966808A5061050137 @default.
- W2144966808 hasAuthorship W2144966808A5067294494 @default.
- W2144966808 hasAuthorship W2144966808A5089267885 @default.
- W2144966808 hasBestOaLocation W21449668081 @default.
- W2144966808 hasConcept C104317684 @default.
- W2144966808 hasConcept C107635520 @default.
- W2144966808 hasConcept C141231307 @default.
- W2144966808 hasConcept C151730666 @default.
- W2144966808 hasConcept C159047783 @default.
- W2144966808 hasConcept C203014093 @default.
- W2144966808 hasConcept C2522874641 @default.
- W2144966808 hasConcept C2777995582 @default.
- W2144966808 hasConcept C2778950215 @default.
- W2144966808 hasConcept C2780007613 @default.
- W2144966808 hasConcept C28328180 @default.
- W2144966808 hasConcept C2908636952 @default.
- W2144966808 hasConcept C502942594 @default.
- W2144966808 hasConcept C54355233 @default.
- W2144966808 hasConcept C86803240 @default.
- W2144966808 hasConceptScore W2144966808C104317684 @default.
- W2144966808 hasConceptScore W2144966808C107635520 @default.
- W2144966808 hasConceptScore W2144966808C141231307 @default.
- W2144966808 hasConceptScore W2144966808C151730666 @default.
- W2144966808 hasConceptScore W2144966808C159047783 @default.
- W2144966808 hasConceptScore W2144966808C203014093 @default.
- W2144966808 hasConceptScore W2144966808C2522874641 @default.
- W2144966808 hasConceptScore W2144966808C2777995582 @default.
- W2144966808 hasConceptScore W2144966808C2778950215 @default.
- W2144966808 hasConceptScore W2144966808C2780007613 @default.
- W2144966808 hasConceptScore W2144966808C28328180 @default.
- W2144966808 hasConceptScore W2144966808C2908636952 @default.
- W2144966808 hasConceptScore W2144966808C502942594 @default.
- W2144966808 hasConceptScore W2144966808C54355233 @default.
- W2144966808 hasConceptScore W2144966808C86803240 @default.
- W2144966808 hasIssue "5" @default.
- W2144966808 hasLocation W21449668081 @default.
- W2144966808 hasLocation W21449668082 @default.
- W2144966808 hasLocation W21449668083 @default.
- W2144966808 hasLocation W21449668084 @default.
- W2144966808 hasOpenAccess W2144966808 @default.
- W2144966808 hasPrimaryLocation W21449668081 @default.
- W2144966808 hasRelatedWork W1554704762 @default.
- W2144966808 hasRelatedWork W178718938 @default.
- W2144966808 hasRelatedWork W1845941028 @default.
- W2144966808 hasRelatedWork W2023865902 @default.
- W2144966808 hasRelatedWork W2068768661 @default.
- W2144966808 hasRelatedWork W2125377878 @default.
- W2144966808 hasRelatedWork W2141379127 @default.
- W2144966808 hasRelatedWork W2400742395 @default.
- W2144966808 hasRelatedWork W2414469960 @default.
- W2144966808 hasRelatedWork W3112883665 @default.
- W2144966808 hasVolume "48" @default.
- W2144966808 isParatext "false" @default.
- W2144966808 isRetracted "false" @default.
- W2144966808 magId "2144966808" @default.
- W2144966808 workType "article" @default.