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- W2144970341 abstract "Myosin-Binding protein-C (MyBP-C) is a family of accessory proteins of striated muscles that contributes to the assembly and stabilization of thick filaments, and regulates the formation of actomyosin cross-bridges, via direct interactions with both thick myosin and thin actin filaments. Three distinct MyBP-C isoforms have been characterized; cardiac, slow skeletal, and fast skeletal. Numerous mutations in the gene for cardiac MyBP-C (cMyBP-C) have been associated with familial hypertrophic cardiomyopathy (FHC) and have led to increased interest in the regulation and roles of the cardiac isoform. This review will summarize our current knowledge on MyBP-C and its role in modulating contractility, focusing on its interactions with both myosin and actin filaments in cardiac and skeletal muscles." @default.
- W2144970341 created "2016-06-24" @default.
- W2144970341 creator A5013084655 @default.
- W2144970341 creator A5050623823 @default.
- W2144970341 date "2011-01-01" @default.
- W2144970341 modified "2023-10-16" @default.
- W2144970341 title "Myosin Binding Protein-C: A Regulator of Actomyosin Interaction in Striated Muscle" @default.
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- W2144970341 doi "https://doi.org/10.1155/2011/636403" @default.
- W2144970341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3196898" @default.
- W2144970341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22028592" @default.
- W2144970341 hasPublicationYear "2011" @default.
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